Association between executive function and the evolution of behavioral disorders in Alzheimer's disease.
Alzheimer
behavior
cognitive impairment
Journal
International journal of geriatric psychiatry
ISSN: 1099-1166
Titre abrégé: Int J Geriatr Psychiatry
Pays: England
ID NLM: 8710629
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
09
01
2019
revised:
18
04
2020
accepted:
25
04
2020
pubmed:
10
5
2020
medline:
4
3
2021
entrez:
9
5
2020
Statut:
ppublish
Résumé
This study was aimed at evaluating the association between cognitive functioning and the occurrence of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD). The population is derived from the PACO cohort, including 237 patients with prodromal or mild AD. A neuropsychological tests battery exploring verbal and visual memory, language, attention, and executive functions was performed at baseline. BPSD were assessed at 6-, 12-, and 18-month follow-up with neuropsychiatric inventory (NPI). Lower baseline performance on Stroop test interference score was associated with higher subsequent overall NPI scores (P = .006), subscores of anxiety/depression (P = .03), and apathy inventory (P = .01). Conversely, other executive functions, verbal or visual memory, and language performances were not associated with a higher risk of BPSD. Our results suggest that poorer inhibition performance would be associated with a higher risk of 18-month BPSD occurrence, including anxiety, depression, and apathy. A better knowledge of the predictive factors of the BPSDs would make it possible to better identify the patients at risk, to propose preventive strategies and an earlier adapted care. J Am Geriatr Soc 68:-, 2020.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1043-1050Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
González-Salvador MT, Arango C, Lyketsos CG, Barba AC. The stress and psychological morbidity of the Alzheimer patient caregiver. Int J Geriatr Psychiatry. 1999;14(9):701-710.
Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA. 2002;288(12):1475-1483.
Cohen-Mansfield J. Agitation in the elderly. Adv Psychosom Med. 1989;19:101-113.
Kales HC, Gitlin LN, Lyketsos CG. Assessment and management of behavioral and psychological symptoms of dementia. BMJ. 2015;350:h369.
Kolanowski A, Boltz M, Galik E, et al. Determinants of behavioral and psychological symptoms of dementia: a scoping review of the evidence. Nurs Outlook. 2017;65(5):515-529. https://doi.org/10.1016/j.outlook.2017.06.006.
Devanand DP. Behavioral complications and their treatment in Alzheimer's disease. Geriatrics. 1997;52(Suppl 2):S37-S39.
Fernández-Martínez M, Castro J, Molano A, Zarranz JJ, Rodrigo RM, Ortega R. Prevalence of neuropsychiatric symptoms in Alzheimer's disease and vascular dementia. Curr Alzheimer Res. 2008;5(1):61-69.
Koppel J, Goldberg TE, Gordon ML, et al. Relationships between behavioral syndromes and cognitive domains in Alzheimer disease: the impact of mood and psychosis. Am J Geriatr Psychiatry Off J Am Assoc Geriatr Psychiatry. 2012;20(11):994-1000. https://doi.org/10.1097/JGP.0b013e3182358921.
Conde-Sala JL, Turró-Garriga O, Piñán-Hernández S, et al. Effects of anosognosia and neuropsychiatric symptoms on the quality of life of patients with Alzheimer's disease: a 24-month follow-up study. Int J Geriatr Psychiatry. 2016;31(2):109-119. https://doi.org/10.1002/gps.4298.
Kuzis G, Sabe L, Tiberti C, Dorrego F, Starkstein SE. Neuropsychological correlates of apathy and depression in patients with dementia. Neurology. 1999;52(7):1403-1407.
Stern Y. Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord. 2006;20(2):112-117. https://doi.org/10.1097/01.wad.0000213815.20177.19.
Soldan A, Pettigrew C, Albert M. Evaluating cognitive reserve through the prism of preclinical Alzheimer disease. Psychiatr Clin North Am. 2018;41(1):65-77. https://doi.org/10.1016/j.psc.2017.10.006.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944.
Albert MS. Changes in cognition. Neurobiol Aging. 2011;32(Suppl 1):S58-S63. https://doi.org/10.1016/j.neurobiolaging.2011.09.010.
Rouch I, Dorey J-M, Boublay N, et al. Personality, Alzheimer's disease and behavioural and cognitive symptoms of dementia: the PACO prospective cohort study protocol. BMC Geriatr. 2014;14(110):1-10. https://doi.org/10.1186/1471-2318-14-110.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198.
Van der Linden M, Coyette F, Poitrenaud J, et al. L'épreuve de rappel libre / rappel indicé à 16 items (RL/RI-16). Solal; 2004. http://orbi.ulg.ac.be/handle/2268/26018. Accessed December 29, 2017.
Barbeau E, Didic M, Tramoni E, et al. Evaluation of visual recognition memory in MCI patients. Neurology. 2004;62(8):1317-1322. https://doi.org/10.1212/01.WNL.0000120548.24298.DB.
Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Tucson, Ariz: Neuropsychology Press; 1985.
Golden C, Freshwater SM. Stroop Color Word Test: A Manual for Clinical and Experimental Uses. Chicago, IL: Stoelting Co. 1978:
Cardebat D, Démonet JF, Viallard G, Faure S, Puel M, Celsis P. Brain functional profiles in formal and semantic fluency tasks: a SPECT study in normals. Brain Lang. 1996;52(2):305-313. https://doi.org/10.1006/brln.1996.0013.
Lebert F, Pasquier F, Petit H. Behavior assessment in Alzheimer type dementia using the disruptive behavior questionnaire. Presse Medicale Paris Fr. 1996;25(14):665-667.
Wechsler Adult Intelligence Scale (WAIS). http://wilderdom.com/personality/intelligenceWAISWISC.html. Published December 18, 2017. Accessed December 18, 2017.
Deloche G, Metz-Lutz M, Kremin H, et al. Test de Dénomination Orale de 80 Images: DO 80. Paris: ECPA; 1989.
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308-2314.
Robert PH, Berr C, Volteau M, et al. Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease: a one-year follow-up study. Clin Neurol Neurosurg. 2006;108(8):733-736. https://doi.org/10.1016/j.clineuro.2006.02.003.
Dorey J. Personality, behavior and neural networks in healthy subjects and Alzheimer's disease. 2017.
Quaranta D, Vita MG, Bizzarro A, et al. Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease. Dement Geriatr Cogn Disord. 2015;39(3-4):194-206. https://doi.org/10.1159/000369161.
Garcia-Alberca JM, Lara JP, Berthier ML, et al. Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study. Arch Gerontol Geriatr. 2011;52(3):264-269. https://doi.org/10.1016/j.archger.2010.05.004.
Spalletta G, Baldinetti F, Buccione I, et al. Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease. J Neurol. 2004;251(6):688-695. https://doi.org/10.1007/s00415-004-0403-6.
Starr JM, Lonie J. Relationship between behavioural and psychological symptoms of dementia and cognition in Alzheimer's disease. Dement Geriatr Cogn Disord. 2007;24(5):343-347. https://doi.org/10.1159/000108632.
Miyake A, Friedman N, Emerson N, Witzki A, Howerter A, Wager T. The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cogn Psychol. 2000;41:49-100. https://doi.org/10.1006/cogp.1999.0734.
Gay P, Rochat L, Billieux J, d'Acremont M, Van der Linden M. Heterogeneous inhibition processes involved in different facets of self-reported impulsivity: evidence from a community sample. Acta Psychol (Amst). 2008;129(3):332-339. https://doi.org/10.1016/j.actpsy.2008.08.010.
Vogt BA, Finch DM, Olson CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex N Y N 1991. 1992;2(6):435-443.
Zalla T, Joyce C, Szöke A, et al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res. 2004;121(3):207-217.
Rosado-Artalejo C, Carnicero JA, Losa-Reyna J, et al. Global performance of executive function is predictor of risk of frailty and disability in older adults. J Nutr Health Aging. 2017;21(9):980-987. https://doi.org/10.1007/s12603-017-0895-2.
Zucchella C, Bartolo M, Bernini S, Picascia M, Malinverni P, Sinforiani E. Modeling Alzheimer disease through functional independence and participation. Alzheimer Dis Assoc Disord. 2017;31(3):218-224. https://doi.org/10.1097/WAD.0000000000000167.