p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4).
Autophagy
Beclin-1
/ metabolism
Cell Line
Cell Movement
Disease Progression
Humans
Models, Biological
Neoplasm Invasiveness
Neoplasms
/ metabolism
Protein Binding
Sequestosome-1 Protein
/ metabolism
Signal Transduction
TNF Receptor-Associated Factor 6
/ metabolism
Toll-Like Receptor 4
/ metabolism
Ubiquitination
BECN1
TRAF6
autophagy
p62
toll-like receptor 4
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
received:
26
03
2020
revised:
23
04
2020
accepted:
02
05
2020
entrez:
10
5
2020
pubmed:
10
5
2020
medline:
24
2
2021
Statut:
epublish
Résumé
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and autophagy through the TNF (Tumor necrosis factor) receptor-associated factor 6 (TRAF6)-evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) and TRAF6-BECN1 signaling axes, respectively. Having shown that p62 negatively regulates Toll-like receptor 4 (TLR4)-mediated signaling via TRAF6-ECSIT signaling axis, we herein investigated whether p62 is functionally implicated in the TRAF6-BECN1 signaling axis, thereby regulating cancer cell migration and invasion. p62 interacted with TRAF6 and BECN1, to interrupt the functional associations required for TRAF6-BECN1 complex formation, leading to inhibitions of BECN1 ubiquitination and autophagy activation. Importantly, p62-deficient cancer cells, such as p62-knockdown (p62
Identifiants
pubmed: 32384667
pii: cells9051142
doi: 10.3390/cells9051142
pmc: PMC7290749
pii:
doi:
Substances chimiques
Beclin-1
0
SQSTM1 protein, human
0
Sequestosome-1 Protein
0
TNF Receptor-Associated Factor 6
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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