RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase.
DNA breaks
IgH
RNA-binding motifs
activation-induced cytidine deaminase
heterogeneous nuclear ribonucleoprotein K
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 05 2020
26 05 2020
Historique:
pubmed:
10
5
2020
medline:
19
8
2020
entrez:
10
5
2020
Statut:
ppublish
Résumé
Activation-induced cytidine deaminase (AID) is the key enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) to generate antibody memory. Previously, heterogeneous nuclear ribonucleoprotein K (hnRNP K) was shown to be required for AID-dependent DNA breaks. Here, we defined the function of major RNA-binding motifs of hnRNP K, GXXGs and RGGs in the K-homology (KH) and the K-protein-interaction (KI) domains, respectively. Mutation of GXXG, RGG, or both impaired CSR, SHM, and
Identifiants
pubmed: 32385154
pii: 1921115117
doi: 10.1073/pnas.1921115117
pmc: PMC7261133
doi:
Substances chimiques
Antibodies
0
Heterogeneous-Nuclear Ribonucleoprotein K
0
Immunoglobulin Heavy Chains
0
AICDA (activation-induced cytidine deaminase)
EC 3.5.4.-
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11624-11635Déclaration de conflit d'intérêts
The authors declare no competing interest.
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