Potency of Oral Rehydration Solution in Inducing Fluid Absorption is Related to Glucose Concentration.
Bicarbonates
/ pharmacology
Caco-2 Cells
Child
Diarrhea
/ metabolism
Fluid Therapy
/ methods
Glucose
/ metabolism
Humans
Intestinal Absorption
/ drug effects
Osmolar Concentration
Potassium
/ metabolism
Potassium Chloride
/ pharmacology
Rehydration Solutions
/ pharmacology
Saline Solution
/ pharmacology
Sodium
/ metabolism
Sodium Chloride
/ pharmacology
Sodium-Glucose Transporter 1
/ genetics
Water-Electrolyte Balance
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 05 2020
08 05 2020
Historique:
received:
03
09
2019
accepted:
14
04
2020
entrez:
10
5
2020
pubmed:
10
5
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Oral rehydration solutions (ORSs) is the key treatment of acute diarrhea in children, as it restores the electrolyte balance by stimulating the intestinal sodium/glucose transporter SGLT1 to induce fluid absorption. The World Health Organization (WHO) and The European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) proposed ORSs with different chemical compositions. The main agent of childhood acute gastroenteritis is rotavirus (RV). We evaluate the effects of ORS with different concentration of glucose and sodium on RV induced secretion. Ussing chambers technique was used for electophysiology experiments to evaluate ion fluid flux. ESPGHAN ORS (sodium 60 mmol/L and glucose 111 mmol/L) induced a more potent proabsorptive effect in Caco-2 cells than WHO ORS, and this effect depended on the sodium/glucose ratio. Titration experiments showed that RV-induced fluid secretion can be reverted to a proabsorptive direction when sodium and glucose concentration fall in specific ranges, specifically 45-60 mEq/L and 80-110 mM respectively. The results were confirmed by testing commercial ORSs. These findings indicated that ORS proabsorptive potency depends on sodium and glucose concentrations. Optimal ORS composition should be tailored to reduce RV-induced ion secretion by also considering palatability. These in vitro data should be confirmed by clinical trials.
Identifiants
pubmed: 32385331
doi: 10.1038/s41598-020-64818-3
pii: 10.1038/s41598-020-64818-3
pmc: PMC7210290
doi:
Substances chimiques
Bicarbonates
0
Rehydration Solutions
0
Saline Solution
0
Sodium-Glucose Transporter 1
0
World Health Organization oral rehydration solution
0
Sodium Chloride
451W47IQ8X
Potassium Chloride
660YQ98I10
Sodium
9NEZ333N27
Glucose
IY9XDZ35W2
Potassium
RWP5GA015D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7803Références
Nalin, D. R. et al. Comparison of sucrose with glucose in oral therapy of infant diarrhoea. Lancet (London, England) 2, 277–9 (1978).
doi: 10.1016/S0140-6736(78)91686-0
Binder, H. J., Brown, I., Ramakrishna, B. S. & Young, G. P. Oral Rehydration Therapy in the Second Decade of the Twenty-first Century. Curr. Gastroenterol. Rep. 16, 376 (2014).
doi: 10.1007/s11894-014-0376-2
Tate, J. E. et al. Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000-2013. Clin. Infect. Dis. 62, S96–S105 (2016).
doi: 10.1093/cid/civ1013
Wang, H. et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388, 1459–1544 (2016).
doi: 10.1016/S0140-6736(16)31012-1
Burnett, E., Parashar, U. D. & Tate, J. E. Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children <5 years old: 2006–2019. J. Infect. Dis. https://doi.org/10.1093/infdis/jiaa081 (2020).
doi: 10.1093/infdis/jiaa081
pubmed: 32095831
GBD Diarrhoeal Diseases Collaborators, C. et al. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. Infect. Dis. 17, 909–948 (2017).
doi: 10.1016/S1473-3099(17)30276-1
Chen, L., Tuo, B. & Dong, H. Regulation of Intestinal Glucose Absorption by Ion Channels and Transporters. Nutrients 8 (2016).
Hirschhorn, N. The treatment of acute diarrhea in children. An historical and physiological perspective. Am. J. Clin. Nutr. 33, 637–63 (1980).
doi: 10.1093/ajcn/33.3.637
World Health Organization. ORAL REHYDRATION SALTS Production of the new ORS. 1–123 (2006).
Fayad, I. M., Hirschhorn, N., Abu-Zikry, M. & Kamel, M. Hypernatraemia surveillance during a national diarrhoeal diseases control project in Egypt. Lancet (London, England) 339, 389–93 (1992).
doi: 10.1016/0140-6736(92)90079-I
Avery, M. E. & Snyder, J. D. Oral therapy for acute diarrhea. The underused simple solution. N. Engl. J. Med. 323, 891–4 (1990).
doi: 10.1056/NEJM199009273231307
Thillainayagam, A. V., Hunt, J. B. & Farthing, M. J. Enhancing clinical efficacy of oral rehydration therapy: is low osmolality the key? Gastroenterology 114, 197–210 (1998).
doi: 10.1016/S0016-5085(98)70647-X
Recommendations for composition of oral rehydration solutions for the children of Europe. Report of an ESPGAN Working Group. J. Pediatr. Gastroenterol. Nutr. 14, 113–5 (1992).
doi: 10.1097/00005176-199201000-00023
Messahel, S. & Hussain, T. Oral rehydration therapy: a lesson from the developing world. Arch. Dis. Child. 93, 183–4 (2008).
doi: 10.1136/adc.2007.132043
Guarino, A. et al. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe. J. Pediatr. Gastroenterol. Nutr. 46, S81–122 (2008).
doi: 10.1097/MPG.0b013e31816f7b16
Lo Vecchio, A. et al. Comparison of Recommendations in Clinical Practice Guidelines for Acute Gastroenteritis in Children. J. Pediatr. Gastroenterol. Nutr. 63, 226–35 (2016).
doi: 10.1097/MPG.0000000000001133
Ussing, H. H. Transport through biological membranes. Annu. Rev. Physiol. 15, 1–20 (1953).
doi: 10.1146/annurev.ph.15.030153.000245
Herrmann, J. R. & Turner, J. R. Beyond Ussing’s chambers: Contemporary thoughts on integration of transepithelial transport. American Journal of Physiology - Cell Physiology 310, C423–C431 (2016).
doi: 10.1152/ajpcell.00348.2015
De Marco, G. et al. Rotavirus induces a biphasic enterotoxic and cytotoxic response in human-derived intestinal enterocytes, which is inhibited by human immunoglobulins. J. Infect. Dis. 200, 813–9 (2009).
doi: 10.1086/605125
Bump, J. B., Reich, M. R. & Johnson, A. M. Diarrhoeal diseases and the global health agenda: measuring and changing priority. Health Policy Plan. 28, 799–808 (2013).
doi: 10.1093/heapol/czs119
Lexmond, W. S., Rufo, P. A., Fiebiger, E. & Lencer, W. I. Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy. PLoS Negl. Trop. Dis. 9, 1–10 (2015).
doi: 10.1371/journal.pntd.0004098
WHO Drug Information Vol. 16, No. 2, 2002. Available at, http://apps.who.int/medicinedocs/en/d/Js4950e/ . (Accessed: 26th January 2016).
Guarino, A., Albano, F. & Guandalini, S. Oral rehydration: toward a real solution. J. Pediatr. Gastroenterol. Nutr. 33(Suppl 2), S2–12 (2001).
doi: 10.1097/00005176-200110002-00002
Sandhu, B. K. Practical guidelines for the management of gastroenteritis in children. J. Pediatr. Gastroenterol. Nutr. 33(Suppl 2), S36–9 (2001).
doi: 10.1097/00005176-200110002-00007
Berni Canani, R., Buccigrossi, V. & Passariello, A. Mechanisms of action of zinc in acute diarrhea. Curr. Opin. Gastroenterol. 27, 8–12 (2011).
doi: 10.1097/MOG.0b013e32833fd48a
Canani, R. B. et al. Zinc Inhibits Cholera Toxin – Induced, but Not Escherichia coli Heat-Stable Enterotoxin – Induced, Ion Secretion in Human Enterocytes. J. Infect. Dis. 191, 1072–1077 (2005).
doi: 10.1086/428504
Kiers, J. L. et al. Effect of osmolality on net fluid absorption in non-infected and ETEC-infected piglet small intestinal segments. Res. Vet. Sci. 81, 274–9 (2006).
doi: 10.1016/j.rvsc.2005.12.007
World Health Organization. Clinical Management of Acute Diarrhoea. World Health Organization; United Nations Children’s Fund. WHO/UNICEF joint statement: clinical management of acute diarrhea. (2004). Available at, http://apps.who.int/iris/bitstream/10665/68627/1/WHO_FCH_CAH_04.7.pdf . (Accessed: 30th January 2016).
Buccigrossi, V. et al. Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes. PLoS One 9, e99830 (2014).
doi: 10.1371/journal.pone.0099830