Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.
Animals
Antioxidants
/ metabolism
Disease Models, Animal
Drosophila Proteins
Drosophila melanogaster
Drug Synergism
Drug Therapy, Combination
Ethanol
/ administration & dosage
Levodopa
/ administration & dosage
Longevity
/ drug effects
Motor Activity
/ drug effects
Oxidative Stress
/ drug effects
Parkinsonian Disorders
/ drug therapy
Plant Extracts
/ administration & dosage
Propolis
/ administration & dosage
Protein Serine-Threonine Kinases
Drosophila melanogaster
Levodopa induced dyskinesia
PINK1B9
Parkinsonism
Parkinson’s disease
aging
antioxidant activity
catalase
climbing index
lifespan
oxidative stress
propolis
Journal
Journal of complementary & integrative medicine
ISSN: 1553-3840
Titre abrégé: J Complement Integr Med
Pays: Germany
ID NLM: 101313855
Informations de publication
Date de publication:
23 Sep 2020
23 Sep 2020
Historique:
received:
18
05
2019
accepted:
13
10
2019
pubmed:
10
5
2020
medline:
29
6
2021
entrez:
10
5
2020
Statut:
epublish
Résumé
Background The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism. Method The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done. Results Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa. Conclusion Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations.
Identifiants
pubmed: 32386191
doi: 10.1515/jcim-2019-0136
pii: jcim-2019-0136
doi:
Substances chimiques
Antioxidants
0
Drosophila Proteins
0
Plant Extracts
0
Ethanol
3K9958V90M
Levodopa
46627O600J
Propolis
9009-62-5
PINK1 protein, Drosophila
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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