Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis.

Animals Models, Animal Multiple Sclerosis / drug therapy Myelin Sheath Oligodendroglia Regenerative Medicine Remyelination

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
07 05 2020
Historique:
entrez: 11 5 2020
pubmed: 11 5 2020
medline: 24 4 2021
Statut: ppublish

Résumé

Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

Identifiants

DOI: 10.1016/j.stem.2020.03.017 PMID: 32386552
pubmed: 32386552
pii: S1934-5909(20)30139-9
doi: 10.1016/j.stem.2020.03.017
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

617-619

Subventions

Organisme : Medical Research Council
ID : G0701476
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203151/Z/16/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declarations of Interest R.J.M.F. is a scientific advisory board member of Frequency Therapeutics, Rewind Therapeutics, and Biogen and has received research funding from Biogen. D.S.R. has received research funding from Vertex Pharmaceuticals. C.L. is an advisory board member of Merck-Serono, Roche, Rewind Therapeutics, and Biogen.

Auteurs

Bjoern Neumann (B)

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK.

Sarah Foerster (S)

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK.

Chao Zhao (C)

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK.

Benedetta Bodini (B)

Sorbonne Université, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière, GH Pitié-Salpêtrière, Paris, France.

Daniel S Reich (DS)

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA.

Dwight E Bergles (DE)

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Ragnhildur Thóra Káradóttir (RT)

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK.

Catherine Lubetzki (C)

Sorbonne Université, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière, GH Pitié-Salpêtrière, Paris, France.

Luke L Lairson (LL)

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Bernard Zalc (B)

Sorbonne Université, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière, GH Pitié-Salpêtrière, Paris, France.

Bruno Stankoff (B)

Sorbonne Université, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière, GH Pitié-Salpêtrière, Paris, France.

Robin J M Franklin (RJM)

Wellcome-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: rjf1000@cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Problems and Pitfalls of Identifying...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Problems and Pitfalls of Identifying...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Problems and Pitfalls of Identifying...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Problems and Pitfalls of Identifying...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Problems and Pitfalls of Identifying...
questionsmedicales.fr › Professions de santé › Médecine › Médecine régénérative › Problems and Pitfalls of Identifying...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Remyélinisation › Problems and Pitfalls of Identifying...