Outcome of donor lymphocyte infusion for fall in chimerism after hematopoietic stem cell transplant.
Acute Disease
Adult
Chimerism
Graft vs Host Disease
/ diagnosis
Hematopoietic Stem Cell Transplantation
Humans
Immune Tolerance
Immunotherapy, Adoptive
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ diagnosis
Lymphocyte Transfusion
/ methods
Male
Siblings
Transplantation Conditioning
Transplantation, Homologous
Treatment Outcome
ALL
Chimerism
DLI
HSCT
Philadelphia
Journal
Transplant immunology
ISSN: 1878-5492
Titre abrégé: Transpl Immunol
Pays: Netherlands
ID NLM: 9309923
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
02
02
2020
revised:
03
05
2020
accepted:
03
05
2020
pubmed:
11
5
2020
medline:
25
3
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
Achievement of complete donor chimerism after an allogeneic hematopoietic stem cell transplant is necessary for elimination of underlying malignant disease. A decline in donor chimerism may herald an impending relapse and therefore, early recognition and intervention plays an important role in such cases. A 32 year old male patient diagnosed as a case of Philadelphia positive mixed phenotypic acute leukaemia underwent peripheral blood hematopoietic stem cell transplant (HSCT) with his sibling as donor. During follow-up, a fall in donor chimerism was observed from 91.86% on day +37 to 88.83% on day +57 and 85.34% on day +77. Donor Lymphocyte Infusion (DLI) was harvested via apheresis. A dose of 1 × 10
Identifiants
pubmed: 32387585
pii: S0966-3274(20)30023-X
doi: 10.1016/j.trim.2020.101305
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101305Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.