Comprehensive review of Wernicke encephalopathy: pathophysiology, clinical symptoms and imaging findings.
Complications
Cytotoxic and vasogenic edema
MRI
Thiamine
Wernicke encephalopathy
Journal
Japanese journal of radiology
ISSN: 1867-108X
Titre abrégé: Jpn J Radiol
Pays: Japan
ID NLM: 101490689
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
09
04
2020
accepted:
29
04
2020
pubmed:
12
5
2020
medline:
11
3
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
Wernicke's encephalopathy (WE) is a severe and life-threatening illness resulting from vitamin B1 (thiamine) deficiency. The prevalence of WE has been estimated from 0.4 to 2.8%. If not treated properly, severe neurologic disorders such as Korsakoff psychosis and even death may occur. The classical triad of clinical symptoms (abnormal mental state, ataxia, and ophthalmoplegia) is found in only 16-33% of patients on initial examination. The originally described underlying condition of WE is alcoholism, but it accounts for about 50% of causes of WE. Nonalcoholic patients are also affected by WE and likely to present symptoms and radiological imaging findings different from patients with alcoholism, which further complicates the diagnosis of WE. Being familiar with predisposing causes, symptoms and radiological imaging findings of WE is important for radiologists and clinicians when making the diagnosis to start immediate treatment. This review discusses pathophysiologies, underlying causes, clinical symptoms, imaging findings and their mimics.
Identifiants
pubmed: 32390125
doi: 10.1007/s11604-020-00989-3
pii: 10.1007/s11604-020-00989-3
doi:
Substances chimiques
Thiamine
X66NSO3N35
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
809-820Références
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