Variability in retinoblastoma genome stability is driven by age and not heritability.

Age Factors Child Child, Preschool DNA Copy Number Variations Genetic Testing / statistics & numerical data Genomic Instability Germ Cells / metabolism Humans Infant Prevalence Retina / metabolism Retinal Neoplasms / diagnosis Retinoblastoma / diagnosis Retinoblastoma Binding Proteins / genetics Ubiquitin-Protein Ligases / genetics
aqueous humor hereditary liquid biopsy retinoblastoma somatic copy number alterations

Journal

Genes, chromosomes & cancer
ISSN: 1098-2264
Titre abrégé: Genes Chromosomes Cancer
Pays: United States
ID NLM: 9007329

Informations de publication

Date de publication:
10 2020
Historique:
received: 27 03 2020
revised: 02 05 2020
accepted: 05 05 2020
pubmed: 12 5 2020
medline: 19 8 2021
entrez: 12 5 2020
Statut: ppublish

Résumé

Retinoblastoma (RB) is a childhood intraocular cancer initiated by biallelic inactivation of the RB tumor suppressor gene (RB1

Identifiants

DOI: 10.1002/gcc.22859 PMID: 32390242 PMC: PMC7441809
pubmed: 32390242
doi: 10.1002/gcc.22859
pmc: PMC7441809
mid: NIHMS1619212
doi:

Substances chimiques

RB1 protein, human 0
Retinoblastoma Binding Proteins 0
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

584-590

Subventions

Organisme : NCI NIH HHS
ID : K08 CA232344
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY029220
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States

Informations de copyright

© 2020 Wiley Periodicals, Inc.

Références

Genes Chromosomes Cancer. 2014 Jan;53(1):1-14
pubmed: 24249257
Indian J Pediatr. 2017 Dec;84(12):937-944
pubmed: 28620731
Br J Ophthalmol. 2012 Aug;96(8):1084-7
pubmed: 22368262
Ophthalmic Genet. 2018 Jun;39(3):407-409
pubmed: 29286867
J Clin Pathol. 2003 Jan;56(1):26-30
pubmed: 12499428
Eur J Cancer. 2005 Mar;41(5):735-40
pubmed: 15763650
Nat Protoc. 2012 May 03;7(6):1024-41
pubmed: 22555242
EBioMedicine. 2015 Jul 08;2(7):660-70
pubmed: 26288838
Ophthalmology. 1993 Nov;100(11):1677-84
pubmed: 8233394
Hum Mutat. 2009 May;30(5):842-51
pubmed: 19280657
Hum Mol Genet. 2008 May 15;17(10):1363-72
pubmed: 18211953
Cancer Sci. 2009 Mar;100(3):465-71
pubmed: 19183342
Br J Ophthalmol. 2019 Feb 11;:
pubmed: 30745306
Genes Chromosomes Cancer. 2007 Jul;46(7):617-34
pubmed: 17437278
Lancet Oncol. 2013 Apr;14(4):327-34
pubmed: 23498719
Eur J Cancer. 2006 Jan;42(1):65-72
pubmed: 16343894
Mol Cancer Res. 2018 Nov;16(11):1701-1712
pubmed: 30061186
Nat Protoc. 2016 Mar;11(3):616
pubmed: 26914320
Genes Chromosomes Cancer. 2005 Jul;43(3):294-301
pubmed: 15834944
PLoS One. 2016 Apr 26;11(4):e0153323
pubmed: 27115612
JAMA Ophthalmol. 2017 Nov 1;135(11):1221-1230
pubmed: 29049475
Ophthalmol Clin North Am. 2005 Mar;18(1):41-53, viii
pubmed: 15763190
Clin Cancer Res. 2017 Jul 1;23(13):e98-e106
pubmed: 28674118
Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3
pubmed: 5279523
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9391-E9400
pubmed: 30213853
Mol Cancer Res. 2020 Aug;18(8):1166-1175
pubmed: 32434859
JAMA Oncol. 2020 Feb 27;:
pubmed: 32105305

Auteurs

Ashley Polski (A)

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Liya Xu (L)

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California, USA.

Rishvanth K Prabakar (RK)

Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA.

Xiaowu Gai (X)

Center for Personalized Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.

Jonathan W Kim (JW)

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Rachana Shah (R)

Cancer and Blood Disease Institute at Children's Hospital Los Angeles, Los Angeles, California, USA.

Rima Jubran (R)

Cancer and Blood Disease Institute at Children's Hospital Los Angeles, Los Angeles, California, USA.

Peter Kuhn (P)

Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California, USA.
Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.

David Cobrinik (D)

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

James Hicks (J)

Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California, USA.
Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Jesse L Berry (JL)

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
ORCID: 0000-0001-6301-6892

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Cellules › Cellules germinales › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Tumeurs de la rétine › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Tumeurs de la rétine › Rétinoblastome › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines de liaison à la protéine du rétinoblastome › Variability in retinoblastoma genome stability...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Variability in retinoblastoma genome stability...