Tri-Manganese(III) Salen-Based Cryptands: A Metal Cooperative Antioxidant Strategy that Overcomes Ischemic Stroke Damage
Animals
Antioxidants
/ chemical synthesis
Apoptosis
/ drug effects
Brain Ischemia
/ drug therapy
Catalase
/ metabolism
Cells, Cultured
Coordination Complexes
/ chemical synthesis
Disease Models, Animal
Ethylenediamines
/ chemistry
Humans
Ischemic Stroke
/ drug therapy
Male
Manganese
/ chemistry
Molecular Conformation
Neuroprotective Agents
/ chemical synthesis
Optical Imaging
Oxygen
/ metabolism
Rats
Rats, Sprague-Dawley
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
pubmed:
12
5
2020
medline:
14
4
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
Oxidative stress is one of the hallmarks of ischemic stroke. Catalase-based (CAT) biomimetic complexes are emerging as promising therapeutic candidates that are expected to act as neuroprotectants for ischemic stroke by decreasing the damaging effects from H
Identifiants
pubmed: 32390429
doi: 10.1021/jacs.0c03805
doi:
Substances chimiques
Antioxidants
0
Coordination Complexes
0
Ethylenediamines
0
Neuroprotective Agents
0
Manganese
42Z2K6ZL8P
disalicylaldehyde ethylenediamine
94-93-9
Catalase
EC 1.11.1.6
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM