Paget disease of the breast: A national retrospective analysis of the US population.
NCDB
Paget’s disease
breast
characteristics
survival
Journal
Breast disease
ISSN: 1558-1551
Titre abrégé: Breast Dis
Pays: Netherlands
ID NLM: 8801277
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
12
5
2020
medline:
9
7
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
Paget's disease of the breast is rare. The National Cancer Database (NCDB) is one of the largest tumor databases in the United States. We queried the NCDB to identify male and female patients with Paget's disease of the breast who were treated from January 1, 2004, through December 31, 2015. No age limitations were applied. Descriptive statistical analysis and survival analysis were performed. We analyzed the demographic, disease, and treatment characteristics of 7,191 patients with Paget's disease of the breast. The median (range) age was 64 (20-90) years. Only 2.1% of patients were men, and 85.4% were white. The most common treatment was complete mastectomy (65.3%), followed by partial mastectomy (30.3%). Tumor destruction was performed in 0.1% of patients, and 4.3% of patients did not undergo any surgery. We examined survival in the subset of 6,864 patients who were treated surgically with complete mastectomy or partial mastectomy. The 5-year survival rate after surgery was 82.5% (95% CI, 81.1%-83.9%). Factors associated with shorter survival were older age, black race/ethnicity, higher tumor grade, regional lymph node metastasis, higher cancer stage, metastatic cancer, and larger tumor size. Paget's disease of the breast usually affects patients older than 60 years, and the most common treatment is complete mastectomy. The 5-year overall survival rate of patients with Paget's disease of the breast is greater than 80% but is lower among older and black people.
Sections du résumé
BACKGROUND
BACKGROUND
Paget's disease of the breast is rare. The National Cancer Database (NCDB) is one of the largest tumor databases in the United States.
METHODS
METHODS
We queried the NCDB to identify male and female patients with Paget's disease of the breast who were treated from January 1, 2004, through December 31, 2015. No age limitations were applied. Descriptive statistical analysis and survival analysis were performed.
RESULTS
RESULTS
We analyzed the demographic, disease, and treatment characteristics of 7,191 patients with Paget's disease of the breast. The median (range) age was 64 (20-90) years. Only 2.1% of patients were men, and 85.4% were white. The most common treatment was complete mastectomy (65.3%), followed by partial mastectomy (30.3%). Tumor destruction was performed in 0.1% of patients, and 4.3% of patients did not undergo any surgery. We examined survival in the subset of 6,864 patients who were treated surgically with complete mastectomy or partial mastectomy. The 5-year survival rate after surgery was 82.5% (95% CI, 81.1%-83.9%). Factors associated with shorter survival were older age, black race/ethnicity, higher tumor grade, regional lymph node metastasis, higher cancer stage, metastatic cancer, and larger tumor size.
CONCLUSIONS
CONCLUSIONS
Paget's disease of the breast usually affects patients older than 60 years, and the most common treatment is complete mastectomy. The 5-year overall survival rate of patients with Paget's disease of the breast is greater than 80% but is lower among older and black people.
Identifiants
pubmed: 32390594
pii: BD200439
doi: 10.3233/BD-200439
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM