Effectiveness of very low-volume preparation for colonoscopy: A prospective, multicenter observational study.
Aged
Ascorbic Acid
/ administration & dosage
Cathartics
/ administration & dosage
Colon
/ diagnostic imaging
Colonoscopy
/ methods
Colorectal Neoplasms
/ diagnosis
Dose-Response Relationship, Drug
Female
Humans
Italy
Male
Mass Screening
/ methods
Medication Adherence
/ statistics & numerical data
Middle Aged
Polyethylene Glycols
/ administration & dosage
Prospective Studies
Treatment Outcome
Bowel preparation
Colonoscopy
Effectiveness
Polyethylene glycol
Polyethylene glycol plus ascorbate
Tolerability
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
28 Apr 2020
28 Apr 2020
Historique:
received:
10
01
2020
revised:
26
03
2020
accepted:
21
04
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
9
2
2021
Statut:
ppublish
Résumé
The effectiveness of colonoscopy strictly depends on adequate bowel cleansing. Recently, a 1 L polyethylene glycol plus ascorbate (PEG-ASC) solution (Plenvu; Norgine, Harefield, United Kingdom) has been introduced on the evidence of three phase-3 randomized controlled trials, but it had never been tested in the real-life. To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L- PEG solutions in a real-life setting. All patients undergoing a screening or diagnostic colonoscopy after a 4, 2 or 1 L PEG preparation, were consecutively enrolled in 5 Italian centers from September 2018 to February 2019. The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon. The secondary endpoints were the evaluation of tolerability, adherence and safety of the different bowel preparations. Bowel cleansing was assessed through the Boston Bowel Preparation Scale. Adherence was defined as consumption of at least 75% of each dose, while tolerability was evaluated through a semi-quantitative scale. Safety was systematically monitored through adverse events reporting. Overall, 1289 met the inclusion criteria and were enrolled in the study. Of these, 490 patients performed a 4 L-PEG preparation (Selgesse This study supports the effectiveness and tolerability of 1 L PEG-ASC, also showing it is an independent predictor of overall cleansing success, high-quality cleansing of the right colon and of tolerability.
Sections du résumé
BACKGROUND
BACKGROUND
The effectiveness of colonoscopy strictly depends on adequate bowel cleansing. Recently, a 1 L polyethylene glycol plus ascorbate (PEG-ASC) solution (Plenvu; Norgine, Harefield, United Kingdom) has been introduced on the evidence of three phase-3 randomized controlled trials, but it had never been tested in the real-life.
AIM
OBJECTIVE
To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L- PEG solutions in a real-life setting.
METHODS
METHODS
All patients undergoing a screening or diagnostic colonoscopy after a 4, 2 or 1 L PEG preparation, were consecutively enrolled in 5 Italian centers from September 2018 to February 2019. The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon. The secondary endpoints were the evaluation of tolerability, adherence and safety of the different bowel preparations. Bowel cleansing was assessed through the Boston Bowel Preparation Scale. Adherence was defined as consumption of at least 75% of each dose, while tolerability was evaluated through a semi-quantitative scale. Safety was systematically monitored through adverse events reporting.
RESULTS
RESULTS
Overall, 1289 met the inclusion criteria and were enrolled in the study. Of these, 490 patients performed a 4 L-PEG preparation (Selgesse
CONCLUSION
CONCLUSIONS
This study supports the effectiveness and tolerability of 1 L PEG-ASC, also showing it is an independent predictor of overall cleansing success, high-quality cleansing of the right colon and of tolerability.
Identifiants
pubmed: 32390705
doi: 10.3748/wjg.v26.i16.1950
pmc: PMC7201146
doi:
Substances chimiques
Cathartics
0
Polyethylene Glycols
3WJQ0SDW1A
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1950-1961Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors have no proprietary, financial, professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of this manuscript.
Références
Am J Gastroenterol. 2008 May;103(5):1122-30
pubmed: 18445096
Am J Gastroenterol. 2002 Jul;97(7):1696-700
pubmed: 12135020
Gastrointest Endosc. 2006 Jun;63(7):894-909
pubmed: 16733101
Gastroenterology. 2014 Oct;147(4):903-24
pubmed: 25239068
Endoscopy. 2019 Jan;51(1):60-72
pubmed: 30025414
Gastrointest Endosc. 2005 Mar;61(3):378-84
pubmed: 15758907
Gastrointest Endosc. 2018 Mar;87(3):677-687.e3
pubmed: 28803744
Endoscopy. 2019 Jan;51(1):73-84
pubmed: 30025415
Clin Gastroenterol Hepatol. 2016 Aug;14(8):1155-62
pubmed: 27060426
Ann Intern Med. 2009 Jan 6;150(1):1-8
pubmed: 19075198
PLoS One. 2016 Jun 03;11(6):e0154149
pubmed: 27257916
Gastrointest Endosc. 2014 Mar;79(3):448-54
pubmed: 24246797
Int J Colorectal Dis. 2013 Jan;28(1):73-81
pubmed: 22885884
Frontline Gastroenterol. 2013 Apr;4(2):112-119
pubmed: 28839711
Gut. 2012 Jul;61(7):1050-7
pubmed: 21940723
N Engl J Med. 2014 Aug 28;371(9):799-807
pubmed: 25162886
Endoscopy. 2019 Aug;51(8):775-794
pubmed: 31295746