Allergen-Specific Immunotherapy With Liposome Containing CpG-ODN in Murine Model of Asthma Relies on MyD88 Signaling in Dendritic Cells.
Adjuvants, Immunologic
/ administration & dosage
Allergens
/ administration & dosage
Anaphylaxis
/ immunology
Animals
Asthma
/ chemically induced
Dendritic Cells
/ immunology
Desensitization, Immunologic
/ methods
Disease Models, Animal
Drug Delivery Systems
/ methods
Female
Gene Knockout Techniques
Liposomes
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Differentiation Factor 88
/ genetics
Oligodeoxyribonucleotides
/ administration & dosage
Signal Transduction
/ drug effects
Treatment Outcome
MyD88
allergen
asthma
dendritic cell
immunotherapy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
12
2019
accepted:
26
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Changing the immune responses to allergens is the cornerstone of allergen immunotherapy. Allergen-specific immunotherapy that consists of repeated administration of increasing doses of allergen extract is potentially curative. The major inconveniences of allergen-specific immunotherapy include failure to modify immune responses, long-term treatment leading to non-compliance and the potential for developing life-threating anaphylaxis. Here we investigated the effect of a novel liposomal formulation carrying low dose of allergen combined with CpG-ODN, a synthetic TLR9 agonist, on established allergic lung inflammation. We found that challenge with allergen (OVA) encapsulated in cationic liposome induced significantly less severe cutaneous anaphylactic reaction. Notably, short-term treatment (three doses) with a liposomal formulation containing co-encapsulated allergen plus CpG-ODN, but not allergen or CpG-ODN alone, reversed an established allergic lung inflammation and provided long-term protection. This liposomal formulation was also effective against allergens derived from
Identifiants
pubmed: 32391011
doi: 10.3389/fimmu.2020.00692
pmc: PMC7191058
doi:
Substances chimiques
Adjuvants, Immunologic
0
Allergens
0
CPG-oligonucleotide
0
Liposomes
0
Myd88 protein, mouse
0
Myeloid Differentiation Factor 88
0
Oligodeoxyribonucleotides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
692Informations de copyright
Copyright © 2020 Alberca-Custodio, Faustino, Gomes, Nunes, de Siqueira, Labrada, Almeida, Câmara, da Fonseca and Russo.
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