Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration.

muscle differentiation muscle disease muscle regeneration satellite cells skeletal muscle

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2020
Historique:
received: 19 01 2020
accepted: 30 03 2020
entrez: 12 5 2020
pubmed: 12 5 2020
medline: 12 5 2020
Statut: epublish

Résumé

Adult skeletal muscle has a remarkable ability to regenerate. Regeneration of mature muscle fibers is dependent on muscle stem cells called satellite cells. Although they are normally in a quiescent state, satellite cells are rapidly activated after injury, and subsequently proliferate and differentiate to make new muscle fibers. Myogenesis is a highly orchestrated biological process and has been extensively studied, and therefore many parameters that can precisely evaluate regenerating events have been established. However, in some cases, it is necessary to evaluate the completion of regeneration rather than ongoing regeneration. In this study, we establish methods for assessing the myofiber maturation during muscle regeneration. By carefully comparing expression patterns of several muscle regeneration-related genes, we found that expression of

Identifiants

pubmed: 32391357
doi: 10.3389/fcell.2020.00267
pmc: PMC7188918
doi:

Types de publication

Journal Article

Langues

eng

Pagination

267

Informations de copyright

Copyright © 2020 Yoshimoto, Ikemoto-Uezumi, Hitachi, Fukada and Uezumi.

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Auteurs

Yuki Yoshimoto (Y)

Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Madoka Ikemoto-Uezumi (M)

Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Keisuke Hitachi (K)

Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

So-Ichiro Fukada (SI)

Project for Muscle Stem Cell Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.

Akiyoshi Uezumi (A)

Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Classifications MeSH