Akiyoshi Uezumi

Affiliations

Muscle Aging and Regenerative Medicine, Research Team for Geriatric Medicine, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.

Publications (31)

The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.

Cell reports

Avec: Lidan Zhang , Yu-Taro Noguchi , Hiroyuki Nakayama , Takayuki Kaji , Kazutake Tsujikawa , Madoka Ikemoto-Uezumi , Akiyoshi Uezumi , Yoshiaki Okada , Takefumi Doi , Shuichi Watanabe , Thomas Braun , Yasushi Fujio , So-Ichiro Fukada

Desloratadine inhibits heterotopic ossification by suppression of BMP2-Smad1/5/8 signaling.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Avec: Taiki Kusano , Masashi Nakatani , Naoki Ishiguro , Kinji Ohno , Naoki Yamamoto , Mitsuhiro Morita , Harumoto Yamada , Akiyoshi Uezumi , Kunihiro Tsuchida

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife

Avec: Sumiaki Fukuda , Akihiro Kaneshige , Takayuki Kaji , Yu-Taro Noguchi , Yusei Takemoto , Lidan Zhang , Kazutake Tsujikawa , Hiroki Kokubo , Akiyoshi Uezumi , Kazumitsu Maehara , Akihito Harada , Yasuyuki Ohkawa , So-Ichiro Fukada

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.

Cell stem cell

Avec: Akihiro Kaneshige , Takayuki Kaji , Lidan Zhang , Hayato Saito , Ayasa Nakamura , Tamaki Kurosawa , Madoka Ikemoto-Uezumi , Kazutake Tsujikawa , Shigeto Seno , Masatoshi Hori , Yasuyuki Saito , Takashi Matozaki , Kazumitsu Maehara , Yasuyuki Ohkawa , Michael Potente , Shuichi Watanabe , Thomas Braun , Akiyoshi Uezumi , So-Ichiro Fukada

Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an antioxidative-independent mechanism.

Journal of cellular physiology

Avec: Yusei Takemoto , Shoya Inaba , Lidan Zhang , Kazutake Tsujikawa , Akiyoshi Uezumi , So-Ichiro Fukada

Detection of muscle stem cell-derived myonuclei in murine overloaded muscles.

STAR protocols

Avec: Akihiro Kaneshige , Takayuki Kaji , Hayato Saito , Tatsuyoshi Higashimoto , Ayasa Nakamura , Tamaki Kurosawa , Madoka Ikemoto-Uezumi , Akiyoshi Uezumi , So-Ichiro Fukada

Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle.

STAR protocols

Avec: Tamaki Kurosawa , Madoka Ikemoto-Uezumi , Akihiro Kaneshige , So-Ichiro Fukada , Akiyoshi Uezumi

Analyses of Mesenchymal Progenitors in Skeletal Muscle by Fluorescence-Activated Cell Sorting and Tissue Clearing.

Methods in molecular biology (Clifton, N.J.)

Avec: Madoka Ikemoto-Uezumi , Tamaki Kurosawa , Keitaro Minato , Akiyoshi Uezumi

Transgenic Expression of

International journal of molecular sciences

Avec: Tamaki Kurosawa , Keitaro Minato , Madoka Ikemoto-Uezumi , Jun Hino , Kunihiro Tsuchida , Akiyoshi Uezumi

Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.

The Journal of clinical investigation

Avec: Akiyoshi Uezumi , Madoka Ikemoto-Uezumi , Heying Zhou , Tamaki Kurosawa , Yuki Yoshimoto , Masashi Nakatani , Keisuke Hitachi , Hisateru Yamaguchi , Shuji Wakatsuki , Toshiyuki Araki , Mitsuhiro Morita , Harumoto Yamada , Masashi Toyoda , Nobuo Kanazawa , Tatsu Nakazawa , Jun Hino , So-Ichiro Fukada , Kunihiro Tsuchida

Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation.

Frontiers in cell and developmental biology

Avec: Yuki Yoshimoto , Akiyoshi Uezumi , Madoka Ikemoto-Uezumi , Kaori Tanaka , Xinyi Yu , Tamaki Kurosawa , Shinsei Yambe , Kazumitsu Maehara , Yasuyuki Ohkawa , Yusuke Sotomaru , Chisa Shukunami

Lack of vitamin D signalling in mesenchymal progenitors causes fatty infiltration in muscle.

Journal of cachexia, sarcopenia and muscle

Avec: Tohru Hosoyama , Minako Kawai-Takaishi , Hiroki Iida , Yoko Yamamoto , Yuko Nakamichi , Tsuyoshi Watanabe , Marie Takemura , Shigeaki Kato , Akiyoshi Uezumi , Yasumoto Matsui

Ror2 signaling regulated by differential Wnt proteins determines pathological fate of muscle mesenchymal progenitors.

Cell death & disease

Avec: Koki Kamizaki , Mitsuko Katsukawa , Ayano Yamamoto , So-Ichiro Fukada , Akiyoshi Uezumi , Mitsuharu Endo , Yasuhiro Minami

EMBO reports

Avec: Keisuke Hitachi , Masashi Nakatani , Akihiko Takasaki , Yuya Ouchi , Akiyoshi Uezumi , Hiroshi Ageta , Hidehito Inagaki , Hiroki Kurahashi , Kunihiro Tsuchida

Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice.

Stem cell research & therapy

Avec: Nana Takenaka-Ninagawa , Jinsol Kim , Mingming Zhao , Masae Sato , Tatsuya Jonouchi , Megumi Goto , Clémence Kiho Bourgeois Yoshioka , Rukia Ikeda , Aya Harada , Takahiko Sato , Makoto Ikeya , Akiyoshi Uezumi , Masashi Nakatani , Satoru Noguchi , Hidetoshi Sakurai

Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle.

Development (Cambridge, England)

Avec: Naoki Takada , Masaki Takasugi , Yoshiki Nonaka , Tomonori Kamiya , Kazuaki Takemura , Junko Satoh , Shinji Ito , Kosuke Fujimoto , Satoshi Uematsu , Kayo Yoshida , Takashi Morita , Hiroaki Nakamura , Akiyoshi Uezumi , Naoko Ohtani

Depletion of CD206

Nature communications

Avec: Allah Nawaz , Muhammad Bilal , Shiho Fujisaka , Tomonobu Kado , Muhammad Rahil Aslam , Saeed Ahmed , Keisuke Okabe , Yoshiko Igarashi , Yoshiyuki Watanabe , Takahide Kuwano , Koichi Tsuneyama , Ayumi Nishimura , Yasuhiro Nishida , Seiji Yamamoto , Masakiyo Sasahara , Johji Imura , Hisashi Mori , Martin M Matzuk , Fujimi Kudo , Ichiro Manabe , Akiyoshi Uezumi , Takashi Nakagawa , Yumiko Oishi , Kazuyuki Tobe

Roles and Heterogeneity of Mesenchymal Progenitors in Muscle Homeostasis, Hypertrophy, and Disease.

Stem cells (Dayton, Ohio)

Avec: So-Ichiro Fukada , Akiyoshi Uezumi

Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrontestinal stromal signature.

Biochemistry and biophysics reports

Avec: Takashi Chaen , Tamaki Kurosawa , Kazuhisa Kishi , Noriyuki Kaji , Madoka Ikemoto-Uezumi , Akiyoshi Uezumi , Masatoshi Hori

Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.

Cell reports

Avec: Lidan Zhang , Hayato Saito , Tatsuyoshi Higashimoto , Takayuki Kaji , Ayasa Nakamura , Kanako Iwamori , Ryoko Nagano , Daisuke Motooka , Daisuke Okuzaki , Akiyoshi Uezumi , Shigeto Seno , So-Ichiro Fukada

Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging.

Aging cell

Avec: Tamaki Kurosawa , Madoka Ikemoto-Uezumi , Yuki Yoshimoto , Keitaro Minato , Noriyuki Kaji , Takashi Chaen , Eiji Hase , Takeo Minamikawa , Takeshi Yasui , Kazuhide Horiguchi , Satoshi Iino , Masatoshi Hori , Akiyoshi Uezumi

Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration.

Frontiers in cell and developmental biology

Avec: Yuki Yoshimoto , Madoka Ikemoto-Uezumi , Keisuke Hitachi , So-Ichiro Fukada , Akiyoshi Uezumi

Tbx1 regulates inherited metabolic and myogenic abilities of progenitor cells derived from slow- and fast-type muscle.

Cell death and differentiation

Avec: Norio Motohashi , Akiyoshi Uezumi , Atsushi Asakura , Madoka Ikemoto-Uezumi , Shuuichi Mori , Yuhei Mizunoe , Rumi Takashima , Yuko Miyagoe-Suzuki , Shin'ichi Takeda , Kazuhiro Shigemoto

Expression and Functional Analyses of Dlk1 in Muscle Stem Cells and Mesenchymal Progenitors during Muscle Regeneration.

International journal of molecular sciences

Avec: Lidan Zhang , Akiyoshi Uezumi , Takayuki Kaji , Kazutake Tsujikawa , Ditte Caroline Andersen , Charlotte Harken Jensen , So-Ichiro Fukada

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.

Development (Cambridge, England)

Avec: Yu-Taro Noguchi , Miki Nakamura , Nobumasa Hino , Jumpei Nogami , Sayaka Tsuji , Takahiko Sato , Lidan Zhang , Kazutake Tsujikawa , Toru Tanaka , Kohei Izawa , Yoshiaki Okada , Takefumi Doi , Hiroki Kokubo , Akihito Harada , Akiyoshi Uezumi , Manfred Gessler , Yasuyuki Ohkawa , So-Ichiro Fukada

Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice.

International journal of molecular sciences

Avec: Keitaro Minato , Yuki Yoshimoto , Tamaki Kurosawa , Kei Watanabe , Hiroyuki Kawashima , Madoka Ikemoto-Uezumi , Akiyoshi Uezumi

Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation.

Aging cell

Avec: Madoka Ikemoto-Uezumi , Heying Zhou , Tamaki Kurosawa , Yuki Yoshimoto , Masashi Toyoda , Nobuo Kanazawa , Tatsu Nakazawa , Mitsuhiro Morita , Kunihiro Tsuchida , Akiyoshi Uezumi

Retinoic Acid Receptor Agonists Suppress Muscle Fatty Infiltration in Mice.

The American journal of sports medicine

Avec: Hideyuki Shirasawa , Noboru Matsumura , Masaki Yoda , Kazumasa Okubo , Masayuki Shimoda , Akiyoshi Uezumi , Morio Matsumoto , Masaya Nakamura , Keisuke Horiuchi

Dlk1 regulates quiescence in calcitonin receptor-mutant muscle stem cells.

Stem cells (Dayton, Ohio)

Avec: Lidan Zhang , Manami Kubota , Ayasa Nakamura , Takayuki Kaji , Shigeto Seno , Akiyoshi Uezumi , Ditte Caroline Andersen , Charlotte Harken Jensen , So-Ichiro Fukada

Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNFα.

Cell death & disease

Avec: Tamaki Kurosawa , Momo Goto , Noriyuki Kaji , Satoshi Aikiyo , Taiki Mihara , Madoka Ikemoto-Uezumi , Masashi Toyoda , Nobuo Kanazawa , Tatsu Nakazawa , Masatoshi Hori , Akiyoshi Uezumi

The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via

Proceedings of the National Academy of Sciences of the United States of America

Avec: Hiroshi Sakai , Hideaki Uno , Harumi Yamakawa , Kaori Tanaka , Aoi Ikedo , Akiyoshi Uezumi , Yasuyuki Ohkawa , Yuuki Imai

Réseau de co-auteurs

Madoka Ikemoto-Uezumi 15 collaborations

So-Ichiro Fukada 14 collaborations

Tamaki Kurosawa 12 collaborations

Lidan Zhang 8 collaborations

Takayuki Kaji 7 collaborations

Kazutake Tsujikawa 6 collaborations

Yuki Yoshimoto 6 collaborations

Kunihiro Tsuchida 5 collaborations

Yasuyuki Ohkawa 5 collaborations

Masashi Nakatani 4 collaborations

Akihiro Kaneshige 4 collaborations

Ayasa Nakamura 4 collaborations

Masatoshi Hori 4 collaborations

Keitaro Minato 4 collaborations

Yu-Taro Noguchi 3 collaborations

Mitsuhiro Morita 3 collaborations

Kazumitsu Maehara 3 collaborations

Hayato Saito 3 collaborations

Shigeto Seno 3 collaborations

Keisuke Hitachi 3 collaborations

Masashi Toyoda 3 collaborations

Nobuo Kanazawa 3 collaborations

Tatsu Nakazawa 3 collaborations

Noriyuki Kaji 3 collaborations

Yoshiaki Okada 2 collaborations

Takefumi Doi 2 collaborations

Shuichi Watanabe 2 collaborations

Thomas Braun 2 collaborations

Harumoto Yamada 2 collaborations

Yusei Takemoto 2 collaborations

Hiroki Kokubo 2 collaborations

Akihito Harada 2 collaborations

Tatsuyoshi Higashimoto 2 collaborations

Jun Hino 2 collaborations

Heying Zhou 2 collaborations

Kaori Tanaka 2 collaborations

Takahiko Sato 2 collaborations

Takashi Chaen 2 collaborations

Ditte Caroline Andersen 2 collaborations

Charlotte Harken Jensen 2 collaborations

Hiroyuki Nakayama 1 collaboration

Yasushi Fujio 1 collaboration

Taiki Kusano 1 collaboration

Naoki Ishiguro 1 collaboration

Kinji Ohno 1 collaboration

Naoki Yamamoto 1 collaboration

Sumiaki Fukuda 1 collaboration

Yasuyuki Saito 1 collaboration

Takashi Matozaki 1 collaboration

Michael Potente 1 collaboration

Shoya Inaba 1 collaboration

Hisateru Yamaguchi 1 collaboration

Shuji Wakatsuki 1 collaboration

Toshiyuki Araki 1 collaboration

Xinyi Yu 1 collaboration

Shinsei Yambe 1 collaboration

Yusuke Sotomaru 1 collaboration

Chisa Shukunami 1 collaboration

Tohru Hosoyama 1 collaboration

Minako Kawai-Takaishi 1 collaboration

Hiroki Iida 1 collaboration

Yoko Yamamoto 1 collaboration

Yuko Nakamichi 1 collaboration

Tsuyoshi Watanabe 1 collaboration

Marie Takemura 1 collaboration

Shigeaki Kato 1 collaboration

Yasumoto Matsui 1 collaboration

Koki Kamizaki 1 collaboration

Mitsuko Katsukawa 1 collaboration

Ayano Yamamoto 1 collaboration

Mitsuharu Endo 1 collaboration

Yasuhiro Minami 1 collaboration

Akihiko Takasaki 1 collaboration

Yuya Ouchi 1 collaboration

Hiroshi Ageta 1 collaboration

Hidehito Inagaki 1 collaboration

Hiroki Kurahashi 1 collaboration

Nana Takenaka-Ninagawa 1 collaboration

Jinsol Kim 1 collaboration

Mingming Zhao 1 collaboration

Masae Sato 1 collaboration

Tatsuya Jonouchi 1 collaboration

Megumi Goto 1 collaboration

Clémence Kiho Bourgeois Yoshioka 1 collaboration

Rukia Ikeda 1 collaboration

Aya Harada 1 collaboration

Makoto Ikeya 1 collaboration

Satoru Noguchi 1 collaboration

Hidetoshi Sakurai 1 collaboration

Naoki Takada 1 collaboration

Masaki Takasugi 1 collaboration

Yoshiki Nonaka 1 collaboration

Tomonori Kamiya 1 collaboration

Kazuaki Takemura 1 collaboration

Junko Satoh 1 collaboration

Shinji Ito 1 collaboration

Kosuke Fujimoto 1 collaboration

Satoshi Uematsu 1 collaboration

Kayo Yoshida 1 collaboration

Takashi Morita 1 collaboration

Hiroaki Nakamura 1 collaboration

Naoko Ohtani 1 collaboration

Allah Nawaz 1 collaboration

Muhammad Bilal 1 collaboration

Shiho Fujisaka 1 collaboration

Tomonobu Kado 1 collaboration

Muhammad Rahil Aslam 1 collaboration

Saeed Ahmed 1 collaboration

Keisuke Okabe 1 collaboration

Yoshiko Igarashi 1 collaboration

Yoshiyuki Watanabe 1 collaboration

Takahide Kuwano 1 collaboration

Koichi Tsuneyama 1 collaboration

Ayumi Nishimura 1 collaboration

Yasuhiro Nishida 1 collaboration

Seiji Yamamoto 1 collaboration

Masakiyo Sasahara 1 collaboration

Johji Imura 1 collaboration

Hisashi Mori 1 collaboration

Martin M Matzuk 1 collaboration

Fujimi Kudo 1 collaboration

Ichiro Manabe 1 collaboration

Takashi Nakagawa 1 collaboration

Yumiko Oishi 1 collaboration

Kazuyuki Tobe 1 collaboration

Kazuhisa Kishi 1 collaboration

Kanako Iwamori 1 collaboration

Ryoko Nagano 1 collaboration

Daisuke Motooka 1 collaboration

Daisuke Okuzaki 1 collaboration

Eiji Hase 1 collaboration

Takeo Minamikawa 1 collaboration

Takeshi Yasui 1 collaboration

Kazuhide Horiguchi 1 collaboration

Satoshi Iino 1 collaboration

Norio Motohashi 1 collaboration

Atsushi Asakura 1 collaboration

Shuuichi Mori 1 collaboration

Yuhei Mizunoe 1 collaboration

Rumi Takashima 1 collaboration

Yuko Miyagoe-Suzuki 1 collaboration

Shin'ichi Takeda 1 collaboration

Kazuhiro Shigemoto 1 collaboration

Miki Nakamura 1 collaboration

Nobumasa Hino 1 collaboration

Jumpei Nogami 1 collaboration

Sayaka Tsuji 1 collaboration

Toru Tanaka 1 collaboration

Kohei Izawa 1 collaboration

Manfred Gessler 1 collaboration

Kei Watanabe 1 collaboration

Hiroyuki Kawashima 1 collaboration

Hideyuki Shirasawa 1 collaboration

Noboru Matsumura 1 collaboration

Masaki Yoda 1 collaboration

Kazumasa Okubo 1 collaboration

Masayuki Shimoda 1 collaboration

Morio Matsumoto 1 collaboration

Masaya Nakamura 1 collaboration

Keisuke Horiuchi 1 collaboration

Manami Kubota 1 collaboration

Momo Goto 1 collaboration

Satoshi Aikiyo 1 collaboration

Taiki Mihara 1 collaboration

Hiroshi Sakai 1 collaboration

Hideaki Uno 1 collaboration

Harumi Yamakawa 1 collaboration

Aoi Ikedo 1 collaboration

Yuuki Imai 1 collaboration