Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation.

Scx iPSCs ligament retinoic acid single cell analysis tendon tenogenic differentiation

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2022
Historique:
received: 20 09 2021
accepted: 09 02 2022
entrez: 4 4 2022
pubmed: 5 4 2022
medline: 5 4 2022
Statut: epublish

Résumé

The musculoskeletal system is integrated by tendons that are characterized by the expression of scleraxis (Scx), a functionally important transcription factor. Here, we newly developed a tenocyte induction method using induced pluripotent stem cells established from

Identifiants

pubmed: 35372337
doi: 10.3389/fcell.2022.780038
pii: 780038
pmc: PMC8965463
doi:

Types de publication

Journal Article

Langues

eng

Pagination

780038

Informations de copyright

Copyright © 2022 Yoshimoto, Uezumi, Ikemoto-Uezumi, Tanaka, Yu, Kurosawa, Yambe, Maehara, Ohkawa, Sotomaru and Shukunami.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Yuki Yoshimoto (Y)

Department of Molecular Biology and Biochemistry, Biomedical Sciences Major, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Akiyoshi Uezumi (A)

Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Madoka Ikemoto-Uezumi (M)

Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Kaori Tanaka (K)

Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Xinyi Yu (X)

Department of Molecular Biology and Biochemistry, Biomedical Sciences Major, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Tamaki Kurosawa (T)

Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Laboratory of Veterinary Pharmacology, Department of Veterinary Medical Sciences, Graduate School of Agriculture and Life Sciences, Tokyo University, Tokyo, Japan.

Shinsei Yambe (S)

Department of Molecular Biology and Biochemistry, Biomedical Sciences Major, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Kazumitsu Maehara (K)

Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Yasuyuki Ohkawa (Y)

Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Yusuke Sotomaru (Y)

Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan.

Chisa Shukunami (C)

Department of Molecular Biology and Biochemistry, Biomedical Sciences Major, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Classifications MeSH