USING DICENTRIC DOSE ESTIMATES AND EARLY RADIATION-INDUCED BLOOD CELL COUNT CHANGES OF REAL CASE HISTORIES FOR VALIDATION OF THE HEMODOSE BIODOSIMETRY TOOL.
Journal
Radiation protection dosimetry
ISSN: 1742-3406
Titre abrégé: Radiat Prot Dosimetry
Pays: England
ID NLM: 8109958
Informations de publication
Date de publication:
24 Jul 2020
24 Jul 2020
Historique:
received:
09
03
2020
revised:
15
04
2020
accepted:
17
04
2020
pubmed:
12
5
2020
medline:
24
6
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
HemoDose is a software tool, which estimates absorbed doses based on blood cell counts (BCC). The aim of our study was to validate HemoDose for early dose estimates. Dose estimates generated by HemoDose were compared with dose estimates stored in SEARCH from radiation victims. Moreover, BCC from unirradiated donors and corresponding HemoDose dose estimates were analysed. We employed linear or logistic regression analysis. There was a significant correlation between calculated doses by HemoDose based on single and multiple lymphocyte counts when omitting lowest and highest dose estimates. Furthermore, there was a significant correlation between calculated doses by HemoDose based on lymphocyte counts and the estimated doses based on DIC. The dose estimates by HemoDose based on lymphocyte counts and DIC showed a comparable correlation with HARS degrees 0 and 4. In conclusion, HemoDose dose estimation based on early lymphocyte counts appears to be a promising biodosimetry tool under certain considerations.
Identifiants
pubmed: 32391564
pii: 5835642
doi: 10.1093/rpd/ncaa063
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
428-435Informations de copyright
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.