Hepatitis B virus-induced hyperactivation of B cells in chronic hepatitis B patients via TLR4.
Animals
B-Lymphocytes
/ immunology
Case-Control Studies
Cell Proliferation
Disease Models, Animal
Gene Expression Profiling
Gene Expression Regulation
Gene Ontology
Genome, Human
Hepatitis B Vaccines
/ immunology
Hepatitis B virus
/ physiology
Hepatitis B, Chronic
/ genetics
Heterozygote
Humans
Lymphocyte Activation
/ immunology
Mice, Inbred C57BL
Myeloid Differentiation Factor 88
/ metabolism
NF-kappa B
/ metabolism
Reproducibility of Results
Toll-Like Receptor 4
/ metabolism
Vaccination
B cell hyperactivation
NF-κB pathway
TLR4
chronic hepatitis B
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
30
09
2019
revised:
07
02
2020
accepted:
06
03
2020
pubmed:
12
5
2020
medline:
29
4
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
B cell hyperactivation and functional impairment were identified from patients with chronic hepatitis B virus (CHB) infection; however, the underlying mechanism remains unknown. Here, we aim to elucidate the mechanisms responsible for B cell hyperactivation during HBV infection. Peripheral CD19
Identifiants
pubmed: 32391647
doi: 10.1111/jcmm.15202
pmc: PMC7294113
doi:
Substances chimiques
Hepatitis B Vaccines
0
Myeloid Differentiation Factor 88
0
NF-kappa B
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6096-6106Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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