Rapid Synthesis of Nucleoside Triphosphates and Analogues.
cyclotriphosphate
non-hydrolyzable nucleotide analogues
nucleoside 5′-triphosphate
phosphoramidite
phosphorylation
Journal
Current protocols in nucleic acid chemistry
ISSN: 1934-9289
Titre abrégé: Curr Protoc Nucleic Acid Chem
Pays: United States
ID NLM: 101287865
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
4
5
2021
Statut:
ppublish
Résumé
Nucleoside triphosphates (NTPs) are essential biomolecules involved in almost all biological processes, and their study is therefore critical to understanding cellular biology. Here, we describe a chemical synthesis suitable for obtaining both natural and highly modified NTPs, which can, for example, be used as surrogates to probe biological processes. The approach includes the preparation of a reagent that enables the facile introduction and modification of three phosphate units: cyclic pyrophosphoryl P-amidite (c-PyPA), derived from pyrophosphate (P
Substances chimiques
Nucleotides
0
Phosphates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e108Informations de copyright
© 2020 The Authors.
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