[Doxycycline Sensitive Two-Promoter Integrator Based on the TET-ON 3G Transactivator].
gene chains
gene therapy
integrator
oncology
synthetic biology
transactivator
Journal
Molekuliarnaia biologiia
ISSN: 0026-8984
Titre abrégé: Mol Biol (Mosk)
Pays: Russia (Federation)
ID NLM: 0105454
Informations de publication
Date de publication:
Historique:
received:
10
10
2019
accepted:
05
11
2019
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
20
8
2020
Statut:
ppublish
Résumé
A synthetic genetic chain was created-a two-promoter integrator, the activity of the output signal of which is high only with the high activity of two promoters at the input of the chain. The integrator is shown to work by the example of cancer-specific promoters of the human survivin and telomerase genes that can be used for specific transcription of target genes in tumor cells. To create the integrator, we used the well-known TET-ON 3G transactivator, regulated by doxycycline.
Identifiants
pubmed: 32392201
doi: 10.31857/S0026898420020056
doi:
Substances chimiques
BIRC5 protein, human
0
Survivin
0
Trans-Activators
0
Telomerase
EC 2.7.7.49
Tetracycline
F8VB5M810T
Doxycycline
N12000U13O
Types de publication
Journal Article
Langues
rus
Sous-ensembles de citation
IM