Ceramide and Sphingosine 1-Phosphate in Liver Diseases.
ceramide
fibrosis
insulin resistance
obesity
sphingosine 1-phosphate
steatosis
Journal
Molecules and cells
ISSN: 0219-1032
Titre abrégé: Mol Cells
Pays: Korea (South)
ID NLM: 9610936
Informations de publication
Date de publication:
31 May 2020
31 May 2020
Historique:
received:
01
03
2020
revised:
06
04
2020
accepted:
19
04
2020
pubmed:
13
5
2020
medline:
12
11
2020
entrez:
13
5
2020
Statut:
ppublish
Résumé
The liver is an important organ in the regulation of glucose and lipid metabolism. It is responsible for systemic energy homeostasis. When energy need exceeds the storage capacity in the liver, fatty acids are shunted into nonoxidative sphingolipid biosynthesis, which increases the level of cellular ceramides. Accumulation of ceramides alters substrate utilization from glucose to lipids, activates triglyceride storage, and results in the development of both insulin resistance and hepatosteatosis, increasing the likelihood of major metabolic diseases. Another sphingolipid metabolite, sphingosine 1-phosphate (S1P) is a bioactive signaling molecule that acts via S1P-specific G protein coupled receptors. It regulates many cellular and physiological events. Since an increase in plasma S1P is associated with obesity, it seems reasonable that recent studies have provided evidence that S1P is linked to lipid pathophysiology, including hepatosteatosis and fibrosis. Herein, we review recent findings on ceramides and S1P in obesity-mediated liver diseases and the therapeutic potential of these sphingolipid metabolites.
Identifiants
pubmed: 32392908
pii: molcells.2020.0054
doi: 10.14348/molcells.2020.0054
pmc: PMC7264474
doi:
Substances chimiques
Ceramides
0
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
419-430Références
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