Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line.

Cell Line, Tumor Drug Tolerance Genes, Reporter Genomics Green Fluorescent Proteins / metabolism Humans Melanoma / drug therapy Metabolomics Microphthalmia-Associated Transcription Factor Models, Molecular Proteomics Proto-Oncogene Proteins B-raf / genetics Reproducibility of Results Single-Cell Analysis

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
11 05 2020
Historique:
received: 03 04 2019
accepted: 02 04 2020
entrez: 13 5 2020
pubmed: 13 5 2020
medline: 6 8 2020
Statut: epublish

Résumé

The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon drugging. We integrate experiments and theory to determine the trajectories that single BRAF

Identifiants

DOI: 10.1038/s41467-020-15956-9 PMID: 32393797 PMC: PMC7214418
pubmed: 32393797
doi: 10.1038/s41467-020-15956-9
pii: 10.1038/s41467-020-15956-9
pmc: PMC7214418
doi:

Substances chimiques

Microphthalmia-Associated Transcription Factor 0
Green Fluorescent Proteins 147336-22-9
Proto-Oncogene Proteins B-raf EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2345

Subventions

Organisme : NCI NIH HHS
ID : U01 CA217655
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA212231
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209971
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA244118
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007266
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA168585
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197633
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA199090
Pays : United States

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Auteurs

Yapeng Su (Y)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Institute for Systems Biology, Seattle, Washington, USA.
ORCID: 0000-0002-6305-8467

Melissa E Ko (ME)

Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.

Hanjun Cheng (H)

Institute for Systems Biology, Seattle, Washington, USA.

Ronghui Zhu (R)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

Min Xue (M)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Department of Chemistry, University of California, Riverside, Riverside, California, USA.

Jessica Wang (J)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
ORCID: 0000-0003-1421-4969

Jihoon W Lee (JW)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
ORCID: 0000-0002-6749-5111

Luke Frankiw (L)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

Alexander Xu (A)

Institute for Systems Biology, Seattle, Washington, USA.

Stephanie Wong (S)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

Lidia Robert (L)

Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

Kaitlyn Takata (K)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
ORCID: 0000-0003-4864-9741

Dan Yuan (D)

Institute for Systems Biology, Seattle, Washington, USA.

Yue Lu (Y)

Institute for Systems Biology, Seattle, Washington, USA.

Sui Huang (S)

Institute for Systems Biology, Seattle, Washington, USA.

Antoni Ribas (A)

Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA.
Department of Surgery, UCLA, Los Angeles, California, USA.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
ORCID: 0000-0003-3669-8458

Raphael Levine (R)

Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
The Fritz Haber Research Center, The Hebrew University, Jerusalem, Israel.

Garry P Nolan (GP)

Department of Microbiology and Immunology, Stanford University, Stanford, California, USA.

Wei Wei (W)

Institute for Systems Biology, Seattle, Washington, USA.
Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
ORCID: 0000-0002-1018-7708

Sylvia K Plevritis (SK)

Department of Radiology, Stanford University, Stanford, California, USA.

Guideng Li (G)

Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. lgd@ism.cams.cn.
Suzhou Institute of Systems Medicine, Suzhou, China. lgd@ism.cams.cn.
ORCID: 0000-0003-0840-7262

David Baltimore (D)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA. baltimo@caltech.edu.
ORCID: 0000-0001-8723-8190

James R Heath (JR)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA. jheath@systemsbiology.org.
Institute for Systems Biology, Seattle, Washington, USA. jheath@systemsbiology.org.
Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA. jheath@systemsbiology.org.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA. jheath@systemsbiology.org.
ORCID: 0000-0001-5356-4385

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Tolérance aux médicaments › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Protéines à fluorescence verte › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Facteur de transcription associé à la microphtalmie › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Multi-omic single-cell snapshots reveal...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Multi-omic single-cell snapshots reveal...