HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.
Adenosine
/ analogs & derivatives
Biopsy
Carcinogenesis
/ genetics
Carcinoma, Hepatocellular
/ genetics
DNA Methylation
/ immunology
Epigenesis, Genetic
/ immunology
Gene Expression Regulation, Neoplastic
/ immunology
Hep G2 Cells
Hepatitis B virus
/ immunology
Hepatitis B, Chronic
/ genetics
Humans
Immunity, Innate
/ genetics
Interferon Regulatory Factor-3
/ metabolism
Liver
/ immunology
Liver Neoplasms
/ genetics
PTEN Phosphohydrolase
/ genetics
Phosphorylation
/ genetics
RNA Stability
/ genetics
RNA, Messenger
/ metabolism
Tumor Escape
/ genetics
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
08
01
2020
revised:
10
04
2020
accepted:
15
04
2020
pubmed:
13
5
2020
medline:
10
8
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
Epitranscriptomic modification of RNA has emerged as the most prevalent form of regulation of gene expression that affects development, differentiation, metabolism, viral infections, and most notably cancer. We have previously shown that hepatitis B virus (HBV) transcripts are modified by N6 methyladenosine (m Here, we show that HBV significantly increases the m The m
Sections du résumé
BACKGROUND AND AIMS
Epitranscriptomic modification of RNA has emerged as the most prevalent form of regulation of gene expression that affects development, differentiation, metabolism, viral infections, and most notably cancer. We have previously shown that hepatitis B virus (HBV) transcripts are modified by N6 methyladenosine (m
APPROACH AND RESULTS
Here, we show that HBV significantly increases the m
CONCLUSIONS
The m
Identifiants
pubmed: 32394474
doi: 10.1002/hep.31313
pmc: PMC7655655
mid: NIHMS1603000
pii: 01515467-202102000-00008
doi:
Substances chimiques
IRF3 protein, human
0
Interferon Regulatory Factor-3
0
RNA, Messenger
0
N-methyladenosine
CLE6G00625
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-547Subventions
Organisme : NIAID NIH HHS
ID : R56 AI139234
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139234
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085087
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125350
Pays : United States
Informations de copyright
© 2020 by the American Association for the Study of Liver Diseases.
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