Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials.
Biomarkers
/ blood
Blood Glucose
/ drug effects
Cholesterol, LDL
/ blood
Dietary Supplements
Glycated Hemoglobin
/ drug effects
Humans
Inflammation
/ blood
Inflammation Mediators
/ blood
Insulin Resistance
/ physiology
Lipids
/ blood
Nigella sativa
/ chemistry
Oxidative Stress
/ drug effects
Plant Extracts
/ pharmacology
Randomized Controlled Trials as Topic
/ statistics & numerical data
Triglycerides
/ blood
HDL-cholesterol
LDL-cholesterol
Nigella sativa
insulin resistance
meta-analysis
oxidative stress
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
16
12
2019
revised:
02
04
2020
accepted:
07
04
2020
pubmed:
13
5
2020
medline:
31
10
2020
entrez:
13
5
2020
Statut:
ppublish
Résumé
The aim of this systematic review and meta-analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity among the included studies were assessed using the Cochrane's Q test and I-square (I
Substances chimiques
Biomarkers
0
Blood Glucose
0
Cholesterol, LDL
0
Glycated Hemoglobin A
0
Inflammation Mediators
0
Lipids
0
Plant Extracts
0
Triglycerides
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2586-2608Subventions
Organisme : Qazvin University of Medical Sciences
ID : IR.QUMS.REC.1398.306
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Abdelmeguid, N. E., Fakhoury, R., Kamal, S. M., & Al Wafai, R. J. (2010). Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. Journal of Diabetes, 2, 256-266.
Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A. K., Siddique, N. A., … Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3, 337-352.
Ahmad Alobaidi, A. H. (2014). Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: A prospective, randomized, double-blind trial. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 13, 68-74.
Ali, B., & Blunden, G. (2003). Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17, 299-305.
Alimohammadi, S., Hobbenaghi, R., Javanbakht, J., Kheradmand, D., Mortezaee, R., Tavakoli, M., … Akbari, H. (2016). Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation (retraction of vol 8, 137, 2013). Diagnostic Pathology., 11, 125.
Al-Naqeep, G., Ismail, M., & Yazan, L. S. (2009). Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression. Journal of Functional Foods, 1, 298-303.
Amin, B., & Hosseinzadeh, H. (2016). Black cumin (Nigella sativa) and its active constituent, thymoquinone: An overview on the analgesic and anti-inflammatory effects. Planta Medica, 82, 8-16.
Amin, F., Islam, N., Anila, N., & Gilani, A. (2015). Clinical efficacy of the co-administration of turmeric and black seeds (Kalongi) in metabolic syndrome-a double blind randomized controlled trial-TAK-MetS trial. Complementary Therapies in Medicine, 23, 165-174.
Amini, M., Fallah Huseini, H., Mohtashami, R., Sadeqhi, Z., & Ghamarchehre, M. (2011). Hypolipidemic effects of Nigella sativa L. seeds oil in healthy volunteers: A randomized, double-blind, placebo-controlled clinical trial. Journal of Medicinal Plants, 4, 133-138.
Ansari, Z. M., Nasiruddin, M., Khan, R. A., & Haque, S. F. (2017). Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial. Saudi Journal of Kidney Diseases and Transplantation: An Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 28, 9-14.
Asayama, K., Uchida, N., Nakane, T., Hayashibe, H., Dobashi, K., Amemiya, S., … Nakazawa, S. (1993). Antioxidants in the serum of children with insulin-dependent diabetes mellitus. Free Radical Biology and Medicine, 15, 597-602.
Askari, G., Rouhani, M. H., Ghaedi, E., Ghavami, A., Nouri, M., & Mohammadi, H. (2019). Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta-analysis of clinical trials. Phytotherapy Research, 33, 1341-1352.
Badar, A., Kaatabi, H., Bamosa, A., Al-Elq, A., Abou-Hozaifa, B., Lebda, F., … Al-Almaie, S. (2017). Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: Nonrandomized clinical trial. Annals of Saudi Medicine, 37, 56-63.
Badary, O. A., Taha, R. A., Gamal El-Din, A. M., & Abdel-Wahab, M. H. (2003). Thymoquinone is a potent superoxide anion scavenger. Drug and Chemical Toxicology, 26, 87-98.
Bamosa, A., Kaatabi, H., Badar, A., Al-Khadra, A., Al Elq, A., Abou-Hozaifa, B., … Al-Almaie, S. (2015). Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus. Journal of Family & Community Medicine, 22, 88-95.
Bamosa, A. O., Ali, B. A., & Sowayan, S. (1997). Effect of oral ingestion Nigella sativa seeds on some blood parameters. Saudi Pharmaceutical Journal, 5, 126-129.
Bashar, T., Misbahuddin, M., & Hossain, M. A. (2014). A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients. Bangladesh Journal of Pharmacology, 9, 15-21.
Bilal, A. (2008). Effects of different preparations of Nigella sativa (ns) on glucose and lipid metabolism in type II diabetic patients. Rawalpindi, Pakistan: Pir Mehr Ali Shah Arid Agriculture University.
Bilal, A., Masud, T., Uppal, A. M., & Naveed, A. K. (2009). Effects of Nigella sativa oil on some blood parameters in type 2 diabetes mellitus patients. Asian Journal of Chemistry, 21, 5373.
Bin Sayeed, M. S., Asaduzzaman, M., Morshed, H., Hossain, M. M., Kadir, M. F., & Rahman, M. R. (2013). The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. Journal of Ethnopharmacology, 148, 780-786.
Burits, M., & Bucar, F. (2000). Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research: PTR., 14, 323-328.
Calder, P. C. (2012). Mechanisms of action of (n-3) fatty acids. The Journal of Nutrition, 142, 592S-599S.
Cheikh-Rouhou, S., Besbes, S., Hentati, B., Blecker, C., Deroanne, C., & Attia, H. (2007). Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food Chemistry, 101, 673-681.
Cicero, A. F. G., Colletti, A., Bajraktari, G., Descamps, O., Djuric, D. M., Ezhov, M., … Banach, M. (2017). Lipid lowering nutraceuticals in clinical practice: Position paper from an international lipid expert panel. Archives of Medical Science, 13, 965-1005.
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003). Oxidative DNA damage: Mechanisms, mutation, and disease. The FASEB Journal, 17, 1195-1214.
Coutinho, M., Gerstein, H. C., Wang, Y., & Yusuf, S. (1999). The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care, 22, 233-240.
Darand, M., Darabi, Z., Yari, Z., Hedayati, M., Shahrbaf, M. A., Khoncheh, A., … Hekmatdoost, A. (2019). The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial. Phytotherapy Research, 33, 2369-2377.
Darand, M., Darabi, Z., Yari, Z., Saadati, S., Hedayati, M., Khoncheh, A., … Hekmatdoost, A. (2019). Nigella sativa and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Results from a randomized, double-blind, placebo-controlled, clinical trial. Complementary Therapies in Medicine, 44, 204-209.
Daryabeygi-Khotbehsara, R., Golzarand, M., Ghaffari, M. P., & Djafarian, K. (2017). Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis. Complementary Therapies in Medicine, 35, 6-13.
Datau, E., Surachmanto, E., Pandelaki, K., & Langi, J. (2010). Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Medica Indonesiana, 42, 130-134.
de Jong, A., Plat, J., & Mensink, R. P. (2003). Metabolic effects of plant sterols and stanols. The Journal of Nutritional Biochemistry, 14, 362-369.
Dehkordi, F. R., & Kamkhah, A. F. (2008). Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology, 22, 447-452.
Develi, S., Evran, B., Kalaz, E. B., Koçak-Toker, N., & Erata, G. Ö. (2014). Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats. Chinese Journal of Natural Medicines, 12, 495-499.
Dubey, P., Singh, B., Mishra, B., Kant, K., & Solanki, R. (2016). Nigella (Nigella sativa L.): A high value seed spice with immense medicinal potential. Indian Journal of Agricultural Science, 86, 967-979.
Elfouly, A. E., Ismail, M. A., Kamal, H. M., Ahmed, S. A., & Fiala, L. E. (2019). A randomized controlled trial measuring the effect of Nigella sativa extract on lipid profile in adult patients with dyslipidemia attending family practice clinic. Ismailia, Egypt: Suez Canal University Hospital.
Fararh, K., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., & Takewaki, T. (2004). Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Research in Veterinary Science, 77, 123-129.
Fararh, K., Atoji, Y., Shimizu, Y., & Takewaki, T. (2002). Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster. Research in Veterinary Science, 73, 279-282.
Farhangi, M. A., Dehghan, P., & Tajmiri, S. (2018). Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto's thyroiditis. Lipids in Health and Disease, 17, 59.
Farzaneh, E., Nia, F. R., Mehrtash, M., Mirmoeini, F. S., & Jalilvand, M. (2014). The effects of 8-week Nigella sativa supplementation and aerobic training on lipid profile and VO2 max in sedentary overweight females. International Journal of Preventive Medicine, 5, 210-216.
Fatima, A., Shad, M. N., & Asrar, A. (2014). Effects of Nigella sativa on HDL-c & body weight. Change, 11, 2.11.
Gackowski, D., Speina, E., Zielinska, M., Kowalewski, J., Rozalski, R., Siomek, A., … Olinski, R. (2003). Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer. Cancer Research, 63, 4899-4902.
Gerich, J. E. (2003). Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Archives of Internal Medicine, 163, 1306-1316.
Gholamnezhad, Z., Havakhah, S., & Boskabady, M. H. (2016). Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. Journal of Ethnopharmacology, 190, 372-386.
Gholamnezhad, Z., Keyhanmanesh, R., & Boskabady, M. H. (2015). Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: A review of basic and clinical evidence. Journal of Functional Foods, 17, 910-927.
Gilani, A., Aziz, N., Khurram, I., Chaudhary, K., & Iqbal, A. (2001). Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): A traditional herbal product with multiple medicinal uses. Journal-Pakistan Medical Association., 51, 115-119.
Golkar, P., & Nourbakhsh, V. (2019). Analysis of genetic diversity and population structure in Nigella sativa L. using agronomic traits and molecular markers (SRAP and SCoT). Industrial Crops and Products, 130, 170-178.
Hadi, S., Mirmiran, P., Daryabeygi-Khotbesara, R., & Hadi, V. (2018). Effect of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress among people with type 2 diabetes mellitus: A randomized, double-blind, placebo controlled trial. Progress in Nutrition, 20, 127-133.
Hadi, V., Kheirouri, S., Alizadeh, M., Khabbazi, A., & Hosseini, H. (2016). Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Avicenna Journal of Phytomedicine, 6, 34-43.
Heshmati, J., & Namazi, N. (2015). Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review. Complementary Therapies in Medicine, 23, 275-282.
Heshmati, J., Namazi, N., Memarzadeh, M.-R., Taghizadeh, M., & Kolahdooz, F. (2015). Nigella sativa oil affects glucose metabolism and lipid concentrations in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Food Research International, 70, 87-93.
Hosseini, M., Mirkarimi, S., Amini, M., Mohtashami, R., Kianbakht, S., & Fallah, H. H. (2013). Effects of Nigella sativa L. seed oil in type II diabetic patients: A randomized, double-blind, placebo-controlled clinical trial. Journal of Medicinal Plants, 3, 93-99.
Houcher, Z., Boudiaf, K., Benboubetra, M., & Houcher, B. (2007). Effects of methanolic extract and commercial oil of Nigella sativa L. on blood glucose and antioxidant capacity in alloxan-induced diabetic rats. Pteridines, 18, 8-18.
Hozoori, M., Fallah Hoseini, H., Kolahdooz, M., Nasri, S., & Zadeh, M. S. (2016). The effects of Nigella sativa L. seed oil on BMI, WC and FBS in overweight men: A randomized controlled clinical trial. Advanced Herbal Medicine, 2, 35-41.
Ibrahim, R. M., Hamdan, N. S., Ismail, M., Saini, S. M., Abd Rashid, S. N., Abd Latiff, L., & Mahmud, R. (2014). Protective effects of Nigella sativa on metabolic syndrome in menopausal women. Advanced Pharmaceutical Bulletin, 4, 29-33.
Ibrahim, R. M., Hamdan, N. S., Mahmud, R., Imam, M. U., Saini, S. M., Rashid, S. N. A., … Ismail, M. (2014). A randomised controlled trial on hypolipidemic effects of Nigella sativa seeds powder in menopausal women. Journal of Translational Medicine, 12, 82.
Ilhan, N., & Ilhan, N. (2003). Vascular endothelial growth factor and oxidative damage in cancer. Clinical Biochemistry, 36, 225-228.
Iqbal, M. S., Ghafoor, A., Abbasi, F. M., Qureshi, A. S., & Ahmad, H. (2011). Study of nutritional characteristics, mineral nutrients and agro-biodiversity in black cumin (Nigella sativa L.) genotypes from Pakistan. African Journal of Biotechnology, 10, 14757-14766.
Kaatabi, H., Bamosa, A. O., Badar, A., Al-Elq, A., Abou-Hozaifa, B., Lebda, F., … Al-Almaie, S. (2015). Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: Placebo controlled participant blinded clinical trial. PLoS One, 10, e0113486.
Khan, M. A. (1999). Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology, 7, 15-35.
Kheirouri, S., Hadi, V., & Alizadeh, M. (2016). Immunomodulatory effect of Nigella sativa oil on T lymphocytes in patients with rheumatoid arthritis. Immunological Investigations, 45, 271-283.
Khonche, A., Huseini, H. F., Gholamian, M., Mohtashami, R., Nabati, F., & Kianbakht, S. (2019). Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial. Journal of Ethnopharmacology, 234, 106-111.
King, G. L., & Wakasaki, H. (1999). Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes. Diabetes Care, 22, C31.
Kooti, W., Hasanzadeh-Noohi, Z., Sharafi-Ahvazi, N., Asadi-Samani, M., & Ashtary-Larky, D. (2016). Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chinese Journal of Natural Medicines, 14, 732-745.
Latiff, L. A., Parhizkar, S., Dollah, M. A., & Hassan, S. T. S. (2014). Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: A novel role of Nigella sativa. Iranian Journal of Basic Medical Sciences, 17, 980.
Levitan, E. B., Song, Y., Ford, E. S., & Liu, S. (2004). Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Archives of Internal Medicine, 164, 2147-2155.
Li, C., Miao, X., Li, F., Wang, S., Liu, Q., Wang, Y., & Sun, J. (2017). Oxidative stress-related mechanisms and antioxidant therapy in diabetic retinopathy. Oxidative Medicine and Cellular Longevity, 2017, 1-15.
Madsen, E. L., Rissanen, A., Bruun, J. M., Skogstrand, K., Tonstad, S., Hougaard, D. M., & Richelsen, B. (2008). Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: A 3-year weight loss study. European Journal of Endocrinology, 158, 179-187.
Mahdavi, R., Alizadeh, M., Namazi, N., & Farajnia, S. (2016). Changes of body composition and circulating adipokines in response to Nigella sativa oil with a calorie restricted diet in obese women. Journal of Herbal Medicine, 6, 67-72.
Mahdavi, R., Namazi, N., Alizadeh, M., & Farajnia, S. (2015). Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: A randomized controlled clinical trial. Food & Function, 6, 2041-2048.
Mahdavi, R., Namazi, N., Alizadeh, M., & Farajnia, S. (2016). Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial. Journal of Clinical Lipidology, 10, 1203-1211.
Mansour, M. A., Nagi, M. N., El-Khatib, A. S., & Al-Bekairi, A. M. (2002). Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action. Cell Biochemistry and Function, 20, 143-151.
Mazaheri, Y., Torbati, M., Azadmard-Damirchi, S., & Savage, G. P. (2019). A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil. Food Reviews International, 35, 342-362.
Meddah, B., Ducroc, R., Faouzi, M. E. A., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., … Haddad, P. S. (2009). Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. Journal of Ethnopharmacology, 121, 419-424.
Memon, A. R., Shah, S. S., Memon, A. R., & Naqvi, S. H. R. (2012). Effect of combination of Nigella sativa and Trigonella foenum-graecum with glibenclamide on serum triglycerides, HDL, and creatinine levels in type 2 diabetes mellitus patients. Pakistan Journal of Pharmacology, 29, 1-6.
Meral, I., Yener, Z., Kahraman, T., & Mert, N. (2001). Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. Journal of Veterinary Medicine Series A, 48, 593-599.
Mirmiran, P., Hosseinpour-Niazi, S., Hedayati, M., & Azizi, F. (2015). Effect of Nigella sativa oil extract on lipid profiles in type 2 diabetic patients: A randomized, double blind, placebo-controlled clinical trial. Iranian Journal of Endocrinology and Metabolism, 16, 411-418.
Moeen-Ud-Din, H., Murad, S., & Fatima, A. (2014). Placebo controlled study on comparison of effects of Nigella sativa and nicotinic acid along with low fat diet and physical exercise on LDL-cholesterol and HDL-cholesterol. Pakistan Journal of Medical and Health Sciences, 8, 306-309.
Mohtashami, A. (2019). Effects of bread with Nigella sativa on blood glucose, blood pressure and anthropometric indices in patients with metabolic syndrome. Clinical Nutrition Research, 8, 138-147.
Mohtashami, A., Mahaki, B., Azadbakht, L., & Entezari, M. H. (2016). Effects of bread with Nigella sativa on lipid profiles, apolipoproteins and inflammatory factor in metabolic syndrome patients. Clinical Nutrition Research, 5, 89-95.
Morikawa, T., Xu, F., Kashima, Y., Matsuda, H., Ninomiya, K., & Yoshikawa, M. (2004). Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Organic Letters, 6, 869-872.
Mukhtar, H., Qureshi, A. S., Anwar, F., Mumtaz, M. W., & Marcu, M. (2019). Nigella sativa L. seed and seed oil: Potential sources of high-value components for development of functional foods and nutraceuticals/pharmaceuticals. Journal of Essential Oil Research, 31, 171-183.
Najmi, A., Nasiruddin, M., Khan, R., & Haque, S. F. (2012). Therapeutic effect of Nigella sativa in patients of poor glycemic control. Asian Journal of Pharmaceutical and Clinical Research, 5, 224-228.
Najmi, A., Nasiruddin, M., Khan, R., & Haque, S. F. (2013). Indigenous herbal product Nigella sativa proved effective as an antihypertensive in metabolic syndrome. Asian Journal of Pharmaceutical and Clinical Research, 6, 61-64.
Najmi, A., Nasiruddin, M., Khan, R. A., & Haque, S. F. (2008). Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. International Journal of Diabetes in Developing Countries, 28, 11-14.
Namazi, N., Larijani, B., Ayati, M. H., & Abdollahi, M. (2018). The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis. Journal of Ethnopharmacology, 219, 173-181.
Namazi, N., Mahdavi, R., Alizadeh, M., & Farajnia, S. (2015). Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind controlled clinical trial. Phytotherapy Research, 29, 1722-1728.
Niaz, K., Qudoos, A., Fatima, A., & Murad, S. (2016). Placebo-controlled study on comparison of two herbal hypolipidemic agents. Journal of Drug Delivery and Therapeutics, 6, 7-10.
Nikkhah-Bodaghi, M., Darabi, Z., Agah, S., & Hekmatdoost, A. (2019). The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis. Phytotherapy Research, 33, 1027-1032.
Paarakh, P. M. (2010). Nigella sativa Linn.-A comprehensive review. Indian Journal of Natural Products and Resources, 1(4), 409-429.
Pari, L., & Sankaranarayanan, C. (2009). Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats. Life Sciences, 85, 830-834.
Pelegrin, S., Galtier, F., Chalancon, A., Gagnol, J. P., Barbanel, A. M., Pelissier, Y., … Chevassus, H. (2019). Effects of Nigella sativa seeds (black cumin) on insulin secretion and lipid profile: A pilot study in healthy volunteers. British Journal of Clinical Pharmacology, 85, 1607-1611.
Rachman, P., Akrom, A., & Darmawan, E. (Eds.) (2017). The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk. In IOP Conference Series: Materials Science and Engineering, 259. https://doi.org/10.1088/1757-899X/259/1/012018
Ramadan, M. F. (2007). Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): An overview. International Journal of Food Science & Technology, 42, 1208-1218.
Rashidmayvan, M., Mohammadshahi, M., Seyedian, S. S., & Haghighizadeh, M. H. (2019). The effect of Nigella sativa oil on serum levels of inflammatory markers, liver enzymes, lipid profile, insulin and fasting blood sugar in patients with non-alcoholic fatty liver. Journal of Diabetes & Metabolic Disorders, 18(2), 453-459.
Sabzghabaee, A. M., Dianatkhah, M., Sarrafzadegan, N., Asgary, S., & Ghannadi, A. (2012). Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: A randomized, placebo controlled clinical trial. Medical Archives (Sarajevo, Bosnia and Herzegovina), 66, 198-200.
Sahebkar, A., Beccuti, G., Simental-Mendia, L. E., Nobili, V., & Bo, S. (2016). Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacological Research, 106, 37-50.
Sahebkar, A., Soranna, D., Liu, X., Thomopoulos, C., Simental-Mendia, L. E., Derosa, G., … Parati, G. (2016). A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. Journal of Hypertension, 34, 2127-2135.
Salem, A. M., Bamosa, A. O., Qutub, H. O., Gupta, R. K., Badar, A., Elnour, A., & Afzal, M. N. (2017). Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: A randomized controlled trial. Annals of Saudi Medicine, 37, 64-71.
Salem, M. L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. International Immunopharmacology, 5, 1749-1770.
Salem, M. L., & Hossain, M. S. (2000). In vivo acute depletion of CD8+ T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. International Journal of Immunopharmacology, 22, 707-718.
Santilli, F., Guagnano, M., Vazzana, N., La Barba, S., & Davi, G. (2015). Oxidative stress drivers and modulators in obesity and cardiovascular disease: From biomarkers to therapeutic approach. Current Medicinal Chemistry, 22, 582-595.
Selvin, E., Paynter, N. P., & Erlinger, T. P. (2007). The effect of weight loss on C-reactive protein: A systematic review. Archives of Internal Medicine, 167, 31-39.
Shah, A. S., Khan, G. M., Badshah, A., Shah, S. U., Shah, K. U., Mirza, S. A., … Khan, K. A. (2012). Nigella sativa provides protection against metabolic syndrome. African Journal of Biotechnology, 11, 10919-10925.
Shaterzadeh-Yazdi, H., Noorbakhsh, M. F., Hayati, F., Samarghandian, S., & Farkhondeh, T. (2018). Immunomodulatory and anti-inflammatory effects of Thymoquinone. Cardiovascular & Hematological Disorders Drug Targets, 18, 52-60.
Shawki, M., El Wakeel, L., Shatla, R., El-Saeed, G., Ibrahim, S., & Badary, O. (2013). The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: A pilot study. Epileptic Disorders: International Epilepsy Journal with Videotape, 15, 295-301.
Shawki, M., El Wakeel, L., Shatla, R., Gamila, E.-S., Ibrahim, S., & Badary, O. (2013). The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: A pilot study. Epileptic Disorders, 15, 295-301.
Singh, G., Marimuthu, P., de Heluani, C. S., & Catalan, C. (2005). Chemical constituents and antimicrobial and antioxidant potentials of essential oil and acetone extract of Nigella sativa seeds. Journal of the Science of Food and Agriculture, 85, 2297-2306.
Sterne, J. A., & Egger, M. (2005). Regression methods to detect publication and other bias in meta-analysis. Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments, 99-110. https://doi.org/10.1002/0470870168.ch6
Tabassum, H., Ahmad, A., & Ahmad, I. Z. (2018). Nigella sativa L. and its bioactive constituents as hepatoprotectant: A review. Current Pharmaceutical Biotechnology, 19, 43-67.
Tasawar, Z., Siraj, Z., Ahmad, N., & Lashari, M. H. (2011). The effects of Nigella sativa (Kalonji) on lipid profile in patients with stable coronary artery disease in Multan, Pakistan. Pakistan Journal of Nutrition, 10, 162-167.
Tavakkoli, A., Mahdian, V., Razavi, B. M., & Hosseinzadeh, H. (2017). Review on clinical trials of black seed (Nigella sativa) and its active constituent, thymoquinone. Journal of Pharmacopuncture, 20, 179.
Turner, R. M., Davey, J., Clarke, M. J., Thompson, S. G., & Higgins, J. P. (2012). Predicting the extent of heterogeneity in meta-analysis, using empirical data from the Cochrane Database of Systematic Reviews. International Journal of Epidemiology, 41, 818-827.
Umar, S., Zargan, J., Umar, K., Ahmad, S., Katiyar, C. K., & Khan, H. A. (2012). Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chemico-Biological Interactions, 197, 40-46.
Uz, E., Bayrak, O., Uz, E., Kaya, A., Bayrak, R., Uz, B., … Akcay, A. (2008). Nigella sativa oil for prevention of chronic cyclosporine nephrotoxicity: An experimental model. American Journal of Nephrology, 28, 517-522.
Vanessa Fiorentino, T., Prioletta, A., Zuo, P., & Folli, F. (2013). Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Current Pharmaceutical Design, 19, 5695-5703.
Yaman, İ., & Balikci, E. (2010). Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats. Experimental and Toxicologic Pathology, 62, 183-190.