Relationship Between Platelet Reactivity and Ischemic and Bleeding Events After Percutaneous Coronary Intervention in East Asian Patients: 1-Year Results of the PENDULUM Registry.
Acute Coronary Syndrome
/ blood
Aged
Aged, 80 and over
Coronary Artery Disease
/ blood
Drug-Eluting Stents
Dual Anti-Platelet Therapy
/ adverse effects
Female
Hemorrhage
/ chemically induced
Humans
Japan
Male
Middle Aged
Percutaneous Coronary Intervention
/ adverse effects
Platelet Activation
/ drug effects
Platelet Aggregation Inhibitors
/ adverse effects
Prospective Studies
Purinergic P2Y Receptor Antagonists
/ adverse effects
Recurrence
Registries
Risk Assessment
Risk Factors
Thrombosis
/ blood
Time Factors
Treatment Outcome
P2Y12
antiplatelet therapy
bleeding
ischemic
percutaneous coronary intervention
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
18 05 2020
18 05 2020
Historique:
pubmed:
13
5
2020
medline:
10
3
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
Background The balance between ischemic and bleeding events and their association with platelet reactivity in patients receiving antiplatelet therapy after percutaneous coronary intervention (PCI), which differs among regions, is not fully evaluated for East Asians. We examined ischemic/bleeding events and platelet reactivity in Japanese patients undergoing PCI and determined associations between high/low platelet reactivity and clinical outcomes. Methods and Results PENDULUM (Platelet Reactivity in Patients with Drug Eluting Stent and Balancing Risk of Bleeding and Ischemic Event) is a prospective, multicenter registry of Japanese patients with PCI. Primary end points were incidence of first major adverse cardiac and cerebrovascular events (MACCE) and first major bleeding events at 12 months post-PCI. Platelet reactivity (P2Y
Identifiants
pubmed: 32394794
doi: 10.1161/JAHA.119.015439
pmc: PMC7660889
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Purinergic P2Y Receptor Antagonists
0
Banques de données
UMIN-CTR
['UMIN 000020332']
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e015439Commentaires et corrections
Type : ErratumIn
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