Vascular-Cognitive Impairment following High-Thoracic Spinal Cord Injury Is Associated with Structural and Functional Maladaptations in Cerebrovasculature.
Animals
Cerebrovascular Circulation
/ drug effects
Cholinergic Agonists
/ pharmacology
Cognitive Dysfunction
/ diagnostic imaging
Endothelium, Vascular
/ diagnostic imaging
Male
Middle Cerebral Artery
/ diagnostic imaging
Rats
Rats, Wistar
Spinal Cord Injuries
/ complications
Thoracic Vertebrae
/ injuries
Vasodilation
/ drug effects
cerebrovascular deficit
cognitive impairment
endothelial dysfunction
spinal cord injury
vascular fibrosis
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
pubmed:
13
5
2020
medline:
4
11
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
Individuals living with chronic spinal cord injury (SCI) often exhibit impairments in cognitive function, which impede their rehabilitation and transition into the community. Although a number of clinical studies have demonstrated the impact of impaired cardiovascular control on cognitive impairment, the mechanistic understanding of this deleterious relationship is still lacking. The present study investigates whether chronic disruption of cardiovascular control following experimental SCI results in cerebrovascular decline and vascular cognitive impairment. Fourteen weeks following a high thoracic SCI (at the third thoracic segment), rats were subjected to a battery of
Identifiants
pubmed: 32394805
doi: 10.1089/neu.2019.6913
pmc: PMC7470217
doi:
Substances chimiques
Cholinergic Agonists
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1963-1970Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK104184
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057842
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG050049
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM104357
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138685
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : CIHR
ID : 389694
Pays : Canada
Organisme : CIHR
ID : 415366
Pays : Canada
Organisme : CIHR
ID : 159573
Pays : Canada
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