Mammary analogue secretory carcinoma: A case report.
Anoctamin-1
/ analysis
Cheek
/ pathology
Cytogenetic Analysis
Diagnosis, Differential
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Mammaglobin A
/ analysis
Mammary Analogue Secretory Carcinoma
/ diagnosis
Mouth Mucosa
/ metabolism
Neoplasm Proteins
/ analysis
Oncogene Proteins, Fusion
/ analysis
S100 Proteins
/ analysis
Tunisia
Journal
La Tunisie medicale
ISSN: 2724-7031
Titre abrégé: Tunis Med
Pays: Tunisia
ID NLM: 0413766
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
2
10
2020
Statut:
ppublish
Résumé
Mammary analogue secretory carcinoma is a rare new entity of low-grade malignant tumor of salivary glands. It shared the same histologic features and the chromosomal translocation t(12;15)(p13;q25) as secretory carcinoma of the breast. To highlight the diagnosis approaches and the attitude of management in a case of MASC which is the first case reported in Tunisia. Reported case: A case of MASC of the lower left jugal mucosa was reviewed for its microscopic and immunohistochemical features. Fluorescence in situ hybridization (FISH) for the ETV6-NTRK3 translocation was performed. Surgery was the only treatment required in this case. No signs of local or regional recurrence during the one-year follow-up were noticed. Secretory carcinoma was confused with other salivary gland tumors especially acinic cell carcinoma due to their morphological similarities, making diagnosis dilemma. Fluorescence in-situ hybridization (FISH) is the one definitive finding to confirm the diagnosis of MASC and to differentiate it from the other types of salivary gland tumor. At the present time, no specific therapy is available for patients with MASC.
Sections du résumé
BACKGROUND
BACKGROUND
Mammary analogue secretory carcinoma is a rare new entity of low-grade malignant tumor of salivary glands. It shared the same histologic features and the chromosomal translocation t(12;15)(p13;q25) as secretory carcinoma of the breast.
AIM
OBJECTIVE
To highlight the diagnosis approaches and the attitude of management in a case of MASC which is the first case reported in Tunisia. Reported case: A case of MASC of the lower left jugal mucosa was reviewed for its microscopic and immunohistochemical features. Fluorescence in situ hybridization (FISH) for the ETV6-NTRK3 translocation was performed. Surgery was the only treatment required in this case. No signs of local or regional recurrence during the one-year follow-up were noticed.
COMMENTARIES
CONCLUSIONS
Secretory carcinoma was confused with other salivary gland tumors especially acinic cell carcinoma due to their morphological similarities, making diagnosis dilemma. Fluorescence in-situ hybridization (FISH) is the one definitive finding to confirm the diagnosis of MASC and to differentiate it from the other types of salivary gland tumor. At the present time, no specific therapy is available for patients with MASC.
Substances chimiques
ANO1 protein, human
0
Anoctamin-1
0
ETV6-NTRK3 fusion protein, human
0
Mammaglobin A
0
Neoplasm Proteins
0
Oncogene Proteins, Fusion
0
S100 Proteins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM