Nothing to sneeze at: Histamine and histamine receptors in oral carcinogenesis.
epithelial dysplasia
histamine
histamine receptors
mast cells
oral lichen planus
oral squamous cell carcinoma
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
01
05
2020
received:
28
03
2020
accepted:
05
05
2020
pubmed:
13
5
2020
medline:
16
6
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
Oral squamous cell carcinoma (OSCC), the most common oral malignancy, shows an increasing rate of incidence worldwide. In spite of the recent advances in cancer research, OSCC therapy continues to have unfavourable outcomes, and thus, patient's prognosis remains relatively poor. Current research has been devoted to identifying novel therapeutic targets also in the tumour microenvironment (TME). Histamine and its G-protein-coupled receptors (H1R-H4R) play vital roles in multiple cancer-associated processes in TME, where histamine is mainly produced by mast cells. However, oral epithelial cells were recently shown to produce low concentrations of histamine in autocrine and paracrine modes. These findings, together with the discovery of the high-affinity histamine H4 receptor, have led to a massive increase in our understanding of histamine functions. In this review, we aim to summarize the most recent findings regarding histamine and its receptors and their involvement in oral carcinogenesis-from oral potentially malignant disorders (OPMDs) to invasive OSCC. Importantly, histamine receptors are differentially expressed in OPMDs and OSCC. Furthermore, H1R and H4R are associated with clinicopathological characteristics of OSCC patients, suggesting a role in prognosis. Due to the enormous success of histamine-based medications, histamine receptors may also represent promising and viable drug targets in oral cancer.
Substances chimiques
Receptors, G-Protein-Coupled
0
Receptors, Histamine
0
Receptors, Histamine H4
0
Histamine
820484N8I3
Types de publication
Journal Article
Review
Langues
eng
Pagination
1090-1096Subventions
Organisme : Emil Aaltonen Foundation
Organisme : The Jane and Aatos Erkko Foundation
Organisme : Helsinki University Central Hospital (HUS) Research Funds
Informations de copyright
© 2020 The Authors. Oral Diseases published by John Wiley & Sons Ltd.
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