APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline.

Age Factors Aged Aged, 80 and over Aging / genetics Alleles Apolipoprotein E4 / genetics Cognitive Dysfunction / ethnology Female Genotype Humans Longitudinal Studies Male Middle Aged Risk Factors Sex Factors
Cognitive decline APOE genotype Epidemiology Ethnicity Sex

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837

Informations de publication

Date de publication:
25 09 2020
Historique:
received: 22 08 2019
pubmed: 13 5 2020
medline: 17 2 2021
entrez: 13 5 2020
Statut: ppublish

Résumé

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.

Identifiants

DOI: 10.1093/gerona/glaa116 PMID: 32396611 PMC: PMC7518559
pubmed: 32396611
pii: 5836323
doi: 10.1093/gerona/glaa116
pmc: PMC7518559
doi:

Substances chimiques

Apolipoprotein E4 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1863-1873

Subventions

Organisme : NIA NIH HHS
ID : R01 AG048642
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG054700
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054548
Pays : United States
Organisme : NINDS NIH HHS
ID : U10 NS077308
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG049466
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049663
Pays : United States
Organisme : Medical Research Council
ID : G9901400
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : T32 HD007168
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD050924
Pays : United States
Organisme : Wellcome Trust
ID : GR08002
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : RF1 AG057531
Pays : United States
Organisme : Medical Research Council
ID : G0601022
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R56 AG057548
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003949
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD091058
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS082432
Pays : United States
Organisme : Wellcome Trust
ID : GR066133
Pays : United Kingdom

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Steve R Makkar (SR)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.

Darren M Lipnicki (DM)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.

John D Crawford (JD)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.

Nicole A Kochan (NA)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.

Erico Castro-Costa (E)

Instituto René Rachou da Fundaçaõ Oswaldo Cruz, Rio de Janeiro, Brazil.

Maria Fernanda Lima-Costa (MF)

Instituto René Rachou da Fundaçaõ Oswaldo Cruz, Rio de Janeiro, Brazil.

Breno Satler Diniz (BS)

Department of Psychiatry, Faculty of Medicine University Toronto, Ontario, Canada.
Geriatric Psychiatry Division, Center for Addiction and Mental Health, Toronto, Ontario, Canada.

Carol Brayne (C)

Department of Public Health and Primary Care, Cambridge University, UK.

Blossom Stephan (B)

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Fiona Matthews (F)

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Juan J Llibre-Rodriguez (JJ)

Finlay-Albarrán Faculty of Medical Sciences, Medical University of Havana, Cuba.

Jorge J Llibre-Guerra (JJ)

Institute of Neurology and Neurosurgery, Havana, Cuba.
Memory and Aging Center, UCSF, San Francisco, California.

Adolfo J Valhuerdi-Cepero (AJ)

Medical University of Matanzas, Matanzas, Cuba.

Richard B Lipton (RB)

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York City, New York.

Mindy J Katz (MJ)

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York City, New York.

Cuiling Wang (C)

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York City, New York.

Karen Ritchie (K)

Inserm, U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France.
Université de Montpellier, Montpellier, France.

Sophie Carles (S)

Inserm, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France.
Paris Descartes University, Paris, France.

Isabelle Carriere (I)

Inserm, U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, France.
Université de Montpellier, Montpellier, France.

Nikolaos Scarmeas (N)

1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Taub Institute for Research in Alzheimer's disease and the Aging Brain, Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York city, New York.

Mary Yannakoulia (M)

Department of Nutrition and Dietetics (M.Y.), Harokopio University, Athens, Greece.

Mary Kosmidis (M)

Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Linda Lam (L)

Department of Psychiatry, The Chinese University of Hong Kong.

Wai Chi Chan (WC)

Department of Psychiatry, The Chinese University of Hong Kong.

Ada Fung (A)

Department of Applied Social Sciences, The Hong Kong Polytechnic University.

Antonio Guaita (A)

Golgi Cenci Foundation, Abbiategrasso, Italy.

Roberta Vaccaro (R)

Golgi Cenci Foundation, Abbiategrasso, Italy.

Annalisa Davin (A)

Golgi Cenci Foundation, Abbiategrasso, Italy.

Ki Woong Kim (KW)

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.

Ji Won Han (JW)

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.

Seung Wan Suh (SW)

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.

Steffi G Riedel-Heller (SG)

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.

Susanne Roehr (S)

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.

Alexander Pabst (A)

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.

Mary Ganguli (M)

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Tiffany F Hughes (TF)

Department of Sociology, Anthropology, and Gerontology, Youngstown State University, Youngstown, Ohio.

Beth Snitz (B)

Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Kaarin J Anstey (KJ)

Neuroscience Research Australia, Sydney, Australia.
Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, The Australian National University, Canberra, Australia.

Nicolas Cherbuin (N)

Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, The Australian National University, Canberra, Australia.

Simon Easteal (S)

John Curtin School of Medical Research, College of Health and Medicine, The Australian National University, Canberra, Australia.

Mary N Haan (MN)

University of California, School of Medicine, Department of Epidemiology and Biostatistics, San Francisco, California.

Allison E Aiello (AE)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina.
Carolina Population Center, Chapel Hill, North Carolina.

Kristina Dang (K)

University of California, School of Medicine, Department of Epidemiology and Biostatistics, San Francisco, California.

Tze Pin Ng (T)

Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Qi Gao (Q)

Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Ma Shwe Zin Nyunt (MS)

Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Henry Brodaty (H)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
Dementia Collaborative Research Centre, University of New South Wales Sydney, Sydney, Australia.

Julian N Trollor (JN)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Australia.

Yvonne Leung (Y)

School of Psychology, University of Nottingham Malaysia, Semenyih, Malaysia.

Jessica W Lo (JW)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.

Perminder Sachdev (P)

Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
Dementia Collaborative Research Centre, University of New South Wales Sydney, Sydney, Australia.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Phénomènes génétiques › Génotype › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › APOE ε4 and the Influence of Sex, Age,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › APOE ε4 and the Influence of Sex, Age,...