TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes.
Aedes aegypti mosquito
NS1 protein
TRiC/CCT complex
Zika virus
viral replication
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
08 05 2020
08 05 2020
Historique:
received:
24
03
2020
revised:
02
05
2020
accepted:
06
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
18
2
2021
Statut:
epublish
Résumé
Mosquito-borne Zika virus (ZIKV) can cause congenital microcephaly and Guillain-Barré syndrome, among other symptoms. Specific treatments and vaccines for ZIKV are not currently available. To further understand the host factors that support ZIKV replication, we used mass spectrometry to characterize mammalian proteins that associate with the ZIKV NS1 protein and identified the TRiC/CCT complex as an interacting partner. Furthermore, the suppression of CCT2, one of the critical components of the TRiC/CCT complex, inhibited ZIKV replication in both mammalian cells and mosquitoes. These results highlight an important role for the TRiC/CCT complex in ZIKV infection, suggesting that the TRiC/CCT complex may be a promising therapeutic target.
Identifiants
pubmed: 32397176
pii: v12050519
doi: 10.3390/v12050519
pmc: PMC7290343
pii:
doi:
Substances chimiques
Insect Proteins
0
NS1 protein, zika virus
0
Viral Nonstructural Proteins
0
Chaperonin Containing TCP-1
EC 3.6.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : AI127865
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : AI089992
Pays : International
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127865
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034989
Pays : United States
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