L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus.
Ascorbic Acid
/ pharmacology
Breast Neoplasms
/ genetics
Cell Death
/ drug effects
Cell Line, Tumor
Cell Nucleus
/ metabolism
Endoplasmic Reticulum Stress
/ drug effects
Endoribonucleases
/ metabolism
Female
Humans
JNK Mitogen-Activated Protein Kinases
/ metabolism
RNA-Binding Proteins
/ metabolism
Sequestosome-1 Protein
/ metabolism
Signal Transduction
/ drug effects
Transcription Factor CHOP
/ metabolism
ER stress
IRE–JNK–CHOP signaling
L-ascorbic acid
autophagy
breast cancer
p62/SQSTM1
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
08 May 2020
08 May 2020
Historique:
received:
06
04
2020
revised:
24
04
2020
accepted:
02
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Anticancer effects of L-ascorbic acid (Vitamin C, L-AA) have been reported in various types of cancers. L-AA intake reduces breast cancer recurrence and mortality; however, the role of L-AA in the treatment of breast cancer remains poorly understood. In this study, we investigated the effect and mechanism action of L-AA on breast cancer growth. L-AA inhibited the growth of breast cancer cells by inducing apoptotic cell death at the evaluated treatment concentrations without affecting normal cells. Moreover, L-AA induces autophagosome formation via regulation of mammalian target of rapamycin (
Identifiants
pubmed: 32397306
pii: nu12051351
doi: 10.3390/nu12051351
pmc: PMC7284633
pii:
doi:
Substances chimiques
DDIT3 protein, human
0
P62 protein, human
0
RNA-Binding Proteins
0
SQSTM1 protein, human
0
Sequestosome-1 Protein
0
Transcription Factor CHOP
147336-12-7
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
Endoribonucleases
EC 3.1.-
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Breast Cancer Res Treat. 2013 Jun;139(2):529-37
pubmed: 23660948
Nat Commun. 2018 Jan 8;9(1):95
pubmed: 29311554
Cell Death Differ. 2004 Apr;11(4):381-9
pubmed: 14685163
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42
pubmed: 279931
Free Radic Biol Med. 2009 Jul 1;47(1):27-9
pubmed: 19361554
Indian J Dent Res. 2014 Jul-Aug;25(4):499-504
pubmed: 25307916
Int J Mol Sci. 2017 Sep 12;18(9):
pubmed: 28895911
J Biol Chem. 2004 Mar 19;279(12):11814-24
pubmed: 14701861
Mol Cell. 2016 Jul 7;63(1):34-48
pubmed: 27345151
Nutr Rev. 1999 Jul;57(7):222-4
pubmed: 10453176
J Mol Cell Cardiol. 2016 Jun;95:2-10
pubmed: 26682507
Indian J Med Res. 2016 Oct;144(4):515-524
pubmed: 28256459
Environ Toxicol. 2018 Dec;33(12):1229-1236
pubmed: 30188005
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9
pubmed: 1068480
Oncotarget. 2017 Apr 11;8(15):25032-25045
pubmed: 28212571
Asian Pac J Cancer Prev. 2013;14(6):3663-7
pubmed: 23886162
J Cell Physiol. 2019 Aug;234(8):12562-12568
pubmed: 30618070
Oncotarget. 2017 May 9;8(35):58790-58800
pubmed: 28938597
Oncogene. 2006 Feb 9;25(6):917-28
pubmed: 16247470
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9
pubmed: 18678913
Cancer Lett. 1998 Jan 9;122(1-2):93-9
pubmed: 9464496
Biochem J. 2013 Jan 15;449(2):389-400
pubmed: 23078367
Nutrients. 2019 Apr 28;11(5):
pubmed: 31035414
Nutrients. 2017 Mar 29;9(4):
pubmed: 28353648
Int J Mol Sci. 2019 Feb 22;20(4):
pubmed: 30813301
Annu Rev Pathol. 2008;3:399-425
pubmed: 18039139
Eur J Cancer. 2014 May;50(7):1223-31
pubmed: 24613622
Nat Cell Biol. 2014 Jun;16(6):495-501
pubmed: 24875736
Front Immunol. 2019 Jan 04;9:3083
pubmed: 30662442
Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102
pubmed: 22251901
Ann Oncol. 2008 Nov;19(11):1969-74
pubmed: 18544557
Br J Cancer. 2007 Apr 10;96(7):1062-71
pubmed: 17353921
Int J Cancer. 2001 Feb 15;91(4):563-7
pubmed: 11251982
Ann Intern Med. 2004 Apr 6;140(7):533-7
pubmed: 15068981
Autophagy. 2014 Mar;10(3):431-41
pubmed: 24394643
J Cell Sci. 2017 Apr 1;130(7):1209-1216
pubmed: 28302910
Clin Cancer Res. 2015 Feb 1;21(3):498-504
pubmed: 25165101
Oncol Lett. 2016 Nov;12(5):4270-4276
pubmed: 27895802
Exp Hematol. 2011 Oct;39(10):999-1006
pubmed: 21723843
Ann Oncol. 2010 May;21 Suppl 5:v15-9
pubmed: 20555067
Br J Cancer. 2014 Aug 26;111(5):944-54
pubmed: 24983366
Oncogene. 2008 Oct 27;27(50):6419-33
pubmed: 18955970
Eur J Clin Nutr. 2012 May;66(5):561-8
pubmed: 22127331
N Engl J Med. 1985 Jan 17;312(3):137-41
pubmed: 3880867
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Physiol Rev. 2011 Oct;91(4):1219-43
pubmed: 22013210
Nutrients. 2017 Aug 12;9(8):
pubmed: 28805671
PLoS Pathog. 2019 Apr 24;15(4):e1007541
pubmed: 31017975
Science. 2011 Jan 28;331(6016):456-61
pubmed: 21205641
Cell Physiol Biochem. 2017;44(1):133-151
pubmed: 29130967
Science. 2015 Dec 11;350(6266):1391-6
pubmed: 26541605
J Cell Biochem. 2007 Nov 1;102(4):1002-10
pubmed: 17455238
Cancer. 2012 Apr 15;118(8):2048-58
pubmed: 21953120
Cancer Epidemiol Biomarkers Prev. 2011 Feb;20(2):262-71
pubmed: 21177425
Semin Cancer Biol. 2015 Aug;33:57-66
pubmed: 25814342
FEBS J. 2007 Feb;274(3):630-58
pubmed: 17288551
Food Funct. 2018 Oct 17;9(10):5390-5401
pubmed: 30272083
Oncotarget. 2016 Aug 19;8(51):88386-88400
pubmed: 29179443
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10845-50
pubmed: 11526215
Asian Pac J Cancer Prev. 2012;13(7):3025-9
pubmed: 22994705
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD000980
pubmed: 15495002
Eur J Cancer. 2000 Mar;36(5):636-46
pubmed: 10738129
Cell Death Differ. 2011 Apr;18(4):571-80
pubmed: 21311563
N Engl J Med. 1979 Sep 27;301(13):687-90
pubmed: 384241
Diabetol Metab Syndr. 2018 Mar 14;10:18
pubmed: 29568330
Nat Rev Drug Discov. 2008 Dec;7(12):1013-30
pubmed: 19043451
Pharmgenomics Pers Med. 2019 May 27;12:59-73
pubmed: 31213877
J Physiol Sci. 2012 May;62(3):251-7
pubmed: 22392350
Mol Cancer Res. 2005 Nov;3(11):597-605
pubmed: 16317085
Cancer Res. 2010 Feb 1;70(3):1042-52
pubmed: 20103647
Int J Mol Sci. 2016 Aug 12;17(8):
pubmed: 27529239
Acta Biochim Biophys Sin (Shanghai). 2014 Aug;46(8):629-40
pubmed: 25016584
J Am Coll Nutr. 2003 Feb;22(1):18-35
pubmed: 12569111
World J Surg. 2007 May;31(5):1041-6
pubmed: 17429562
J Alzheimers Dis. 2012;29(4):711-26
pubmed: 22366772
Carcinogenesis. 2016 Mar;37(3):233-44
pubmed: 26762228
Food Funct. 2010 Dec;1(3):301-7
pubmed: 21776480
Onco Targets Ther. 2019 Sep 10;12:7405-7413
pubmed: 31571901
Biol Pharm Bull. 2017;40(9):1337-1343
pubmed: 28867719
Mol Cell Biol. 2001 Feb;21(4):1249-59
pubmed: 11158311
Int J Mol Sci. 2017 Jul 01;18(7):
pubmed: 28671583
Clin Interv Aging. 2013;8:741-8
pubmed: 23818772
PLoS One. 2013 Dec 05;8(12):e81065
pubmed: 24339898
Curr Mol Med. 2016;16(6):533-44
pubmed: 27211800
Mutat Res. 2005 Jan 6;569(1-2):29-63
pubmed: 15603751
Free Radic Biol Med. 2009 Mar 15;46(6):719-30
pubmed: 19162177
J Biol Chem. 2010 Jul 16;285(29):22576-91
pubmed: 20452972
Chem Biol Interact. 1974 Oct;9(4):285-315
pubmed: 4430016
Oncogene. 2013 Mar 21;32(12):1508-17
pubmed: 22665050
Molecules. 2019 Jan 28;24(3):
pubmed: 30695991
J Res Med Sci. 2014 Feb;19(2):164-74
pubmed: 24778671
Front Med (Lausanne). 2017 Dec 08;4:227
pubmed: 29276709
Results Immunol. 2016 Jan 12;6:8-10
pubmed: 27014565
Cell Death Differ. 2006 Mar;13(3):363-73
pubmed: 16397583
Clin Cancer Res. 2016 Aug 15;22(16):4145-57
pubmed: 26983464
Nutrients. 2017 Jun 27;9(7):
pubmed: 28654021
Mol Cell Biol. 2004 Aug;24(15):6645-52
pubmed: 15254232
Clin Cancer Res. 2010 Jan 15;16(2):509-20
pubmed: 20068072
Carcinogenesis. 2014 Apr;35(4):828-39
pubmed: 24343359
Free Radic Biol Med. 2009 Jul 1;47(1):32-40
pubmed: 19254759
Sci Rep. 2019 Aug 7;9(1):11466
pubmed: 31391477
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Biol Trace Elem Res. 2009 Jul;130(1):1-6
pubmed: 19148586
Autophagy. 2011 Mar;7(3):279-96
pubmed: 21189453
Nucleic Acids Res. 2013 Sep;41(16):7683-99
pubmed: 23804767
J Cancer Res Clin Oncol. 2015 Apr;141(4):601-14
pubmed: 25316441
Annu Rev Pathol. 2015;10:173-94
pubmed: 25387057
Acta Biochim Biophys Sin (Shanghai). 2015 Feb;47(2):146-7
pubmed: 25634437
J Pineal Res. 2015 Oct;59(3):292-307
pubmed: 26201382
Mol Nutr Food Res. 2016 Jun;60(6):1458-69
pubmed: 27019217
Nutrients. 2019 Dec 06;11(12):
pubmed: 31817810