Oxidative Phosphorylation Dysfunction Modifies the Cell Secretome.
Biomarkers
/ metabolism
DNA, Mitochondrial
/ genetics
Fibroblast Growth Factors
/ genetics
Growth Differentiation Factor 15
/ genetics
Humans
Interleukin-6
/ metabolism
Mitochondrial Diseases
/ genetics
Oxidative Phosphorylation
Secretory Pathway
/ drug effects
Vascular Endothelial Growth Factor A
/ genetics
biomarkers
fibroblast growth factor 21
growth differentiation factor 15
interleukine-6
mitochondrial DNA
mitochondrial diseases
oxidative phosphorylation system
secretome
vascular endothelial growth factor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 May 2020
10 May 2020
Historique:
received:
18
03
2020
revised:
29
04
2020
accepted:
09
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell's secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials.
Identifiants
pubmed: 32397676
pii: ijms21093374
doi: 10.3390/ijms21093374
pmc: PMC7246988
pii:
doi:
Substances chimiques
Biomarkers
0
DNA, Mitochondrial
0
FGF21 protein, human
0
GDF15 protein, human
0
Growth Differentiation Factor 15
0
IL6 protein, human
0
Interleukin-6
0
Vascular Endothelial Growth Factor A
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : FIS-PI17/00021 and PI17/00166
Organisme : Fundación Mutua Madrileña
ID : MMA17/01
Organisme : Precipita-FECYT crowdfunding program
ID : PR194
Organisme : Gobierno de Aragón
ID : Grupos Consolidados B33_17R
Organisme : Gobierno de Aragón
ID : FEDER 2014-2020 "Construyendo Europa desde Aragón"
Organisme : Asociación de Enfermos de Patología Mitocondrial
ID : (AEPMI)
Organisme : Plan Nacional de I + D + I and Instituto de Salud Carlos III (ISCIII) Subdirección General de Evaluación y Fomento de la Investigación Sanitaria
ID : PI19/0122
Organisme : co-funded with European Regional Development Fund (ERDF)
ID : "A way to achieve Europe".
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