Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.
Animals
Anti-Inflammatory Agents
/ administration & dosage
Cardiovascular Diseases
/ drug therapy
Cathepsins
/ antagonists & inhibitors
Clinical Trials as Topic
/ methods
Comorbidity
Humans
Inflammation Mediators
/ antagonists & inhibitors
Lung
/ drug effects
Lung Diseases
/ drug therapy
Neoplasms
/ drug therapy
Signal Transduction
/ drug effects
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
12 May 2020
12 May 2020
Historique:
received:
03
03
2020
accepted:
01
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
13
3
2021
Statut:
epublish
Résumé
Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number of conditions affecting the lungs. Extracellular CTSS has potent elastase activity and by processing cytokines and host defense proteins, it also plays a role in the regulation of inflammation. CTSS has also been linked to G-coupled protein receptor activation and possesses an important intracellular role in major histocompatibility complex class II antigen presentation. Modulated CTSS activity is also associated with pulmonary disease comorbidities, such as cancer, cardiovascular disease, and diabetes. CTSS is expressed in a wide variety of immune cells and is biologically active at neutral pH. Herein, we review the significance of CTSS signaling in pulmonary diseases and associated comorbidities. We also discuss CTSS as a plausible therapeutic target and describe recent and current clinical trials examining CTSS inhibition as a means for treatment.
Identifiants
pubmed: 32398133
doi: 10.1186/s12931-020-01381-5
pii: 10.1186/s12931-020-01381-5
pmc: PMC7216426
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Inflammation Mediators
0
Cathepsins
EC 3.4.-
cathepsin S
EC 3.4.22.27
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111Subventions
Organisme : Alpha-1 Foundation
ID : 614218
Organisme : Medical Research Council
ID : MR/P022847/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13075
Pays : United Kingdom
Organisme : Rosetrees Trust
ID : A2450
Organisme : Cystic Fibrosis Foundation
ID : WELDON18G0
Organisme : Flight Attendant Medical Research Institute
ID : CIA160005
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