PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.

Acetamides / administration & dosage Adaptor Proteins, Signal Transducing / metabolism Adult Brain / diagnostic imaging Case-Control Studies Female Gene Expression Profiling Healthy Volunteers Humans Male Microglia / immunology Middle Aged Positron-Emission Tomography / methods Pyridines / administration & dosage Radiopharmaceuticals / administration & dosage Receptors, GABA / immunology Receptors, Tumor Necrosis Factor, Member 14 / metabolism Sex Factors Stress Disorders, Post-Traumatic / diagnostic imaging Young Adult

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
12 05 2020
Historique:
received: 03 10 2019
accepted: 31 03 2020
entrez: 14 5 2020
pubmed: 14 5 2020
medline: 1 9 2020
Statut: epublish

Résumé

Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation in individuals with PTSD. [

Identifiants

DOI: 10.1038/s41467-020-15930-5 PMID: 32398677 PMC: PMC7217830
pubmed: 32398677
doi: 10.1038/s41467-020-15930-5
pii: 10.1038/s41467-020-15930-5
pmc: PMC7217830
doi:

Substances chimiques

Acetamides 0
Adaptor Proteins, Signal Transducing 0
N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide 0
Pyridines 0
Radiopharmaceuticals 0
Receptors, GABA 0
Receptors, Tumor Necrosis Factor, Member 14 0
TNFRSF14 protein, human 0
TSPO protein, human 0
TSPOAP1 protein, human 0

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2360

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH110674
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA024788
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : F30 MH116607
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007205
Pays : United States

Investigateurs

Matthew J Girgenti (MJ)
Matthew J Friedman (MJ)
Ronald S Duman (RS)
John H Krystal (JH)

Références

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Auteurs

Shivani Bhatt (S)

Interdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA.
ORCID: 0000-0003-3494-7246

Ansel T Hillmer (AT)

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.

Matthew J Girgenti (MJ)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.
ORCID: 0000-0003-1647-326X

Aleksandra Rusowicz (A)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
ORCID: 0000-0002-8873-9875

Michael Kapinos (M)

Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.

Nabeel Nabulsi (N)

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.
ORCID: 0000-0001-8129-0051

Yiyun Huang (Y)

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.

David Matuskey (D)

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.
ORCID: 0000-0001-7508-6572

Gustavo A Angarita (GA)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.

Irina Esterlis (I)

Interdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.
U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Margaret T Davis (MT)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.

Steven M Southwick (SM)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Matthew J Friedman (MJ)

Neurosciences Center, Dartmouth Medical School, Hanover, NH, 03755, USA.
ORCID: 0000-0002-0497-6890

Ronald S Duman (RS)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
ORCID: 0000-0001-8690-8439

Richard E Carson (RE)

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.
ORCID: 0000-0002-9338-7966

John H Krystal (JH)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Robert H Pietrzak (RH)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Kelly P Cosgrove (KP)

Interdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA. kelly.cosgrove@yale.edu.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA. kelly.cosgrove@yale.edu.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA. kelly.cosgrove@yale.edu.
Yale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA. kelly.cosgrove@yale.edu.
U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, 06516, USA. kelly.cosgrove@yale.edu.
ORCID: 0000-0003-1351-9576

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Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

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Humans Yoga Low Back Pain Female Male

Classifications MeSH

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