Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
24
02
2020
accepted:
23
04
2020
pubmed:
14
5
2020
medline:
2
7
2020
entrez:
14
5
2020
Statut:
ppublish
Résumé
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8
Identifiants
pubmed: 32398875
doi: 10.1038/s41591-020-0901-9
pii: 10.1038/s41591-020-0901-9
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-844Subventions
Organisme : Shenzhen Science and Technology Innovation Commission
ID : 202002073000002
Pays : International
Commentaires et corrections
Type : CommentIn
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