Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.
Aged
Aged, 80 and over
Animals
Cells, Cultured
Diabetes Mellitus
/ genetics
Endothelium, Vascular
/ drug effects
Female
Glycoproteins
/ pharmacology
Humans
Insulin Resistance
/ physiology
Male
Mice
Mice, Knockout
Mice, Transgenic
Middle Aged
NADPH Oxidase 2
/ antagonists & inhibitors
Organ Culture Techniques
Nox2
atherosclerosis
insulin resistance
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
pubmed:
14
5
2020
medline:
22
10
2020
entrez:
14
5
2020
Statut:
ppublish
Résumé
Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Here we examine the therapeutic potential of Nox2 inhibition on superoxide generation in saphenous vein ECs (SVECs) from patients with advanced atherosclerosis and type 2 diabetes and on vascular function, vascular damage, and lipid deposition in apolipoprotein E-deficient (ApoE
Identifiants
pubmed: 32401607
doi: 10.1152/ajpcell.00389.2019
pmc: PMC7468885
doi:
Substances chimiques
Glycoproteins
0
gp91ds-tat protein, chimeric
0
NADPH Oxidase 2
EC 1.6.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
C64-C74Subventions
Organisme : British Heart Foundation (BHF)
ID : CH/1999001/11735
Pays : International
Organisme : British Heart Foundation
ID : FS/17/66/33480
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/13/1/30086
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/14/54/30939
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/1999001/11735
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/15/7/31521
Pays : United Kingdom
Organisme : British Heart Foundation (BHF)
ID : FS/17/66/33480
Pays : International
Organisme : British Heart Foundation (BHF)
ID : CH/13/1/30086
Pays : International
Organisme : British Heart Foundation (BHF)
ID : PG/14/54/30939
Pays : International
Organisme : British Heart Foundation
ID : FS/12/80/29821
Pays : United Kingdom
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