David J Beech

Affiliations

Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, United Kingdom.

Publications (18)

Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells.

eLife

Avec: Vincenza Caolo , Marjolaine Debant , Naima Endesh , T Simon Futers , Laeticia Lichtenstein , Fiona Bartoli , Gregory Parsonage , Elizabeth Av Jones , David J Beech

Force Sensing by Piezo Channels in Cardiovascular Health and Disease.

Arteriosclerosis, thrombosis, and vascular biology

Avec: David J Beech , Antreas C Kalli

Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine.

Annual review of pharmacology and toxicology

Avec: Robin S Bon , David J Wright , David J Beech , Piruthivi Sukumar

Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.

Circulation research

Avec: Hema Viswambharan , Nadira Y Yuldasheva , Helen Imrie , Katherine Bridge , Natalie J Haywood , Anna Skromna , Karen E Hemmings , Emily R Clark , V Kate Gatenby , Paul Cordell , Katie J Simmons , Natallia Makava , Yilizila Abudushalamu , Naima Endesh , Jane Brown , Andrew M N Walker , Simon T Futers , Karen E Porter , Richard M Cubbon , Khalid Naseem , Ajay M Shah , David J Beech , Stephen B Wheatcroft , Mark T Kearney , Piruthivi Sukumar

An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (-)-englerin A.

Archives of toxicology

Avec: Christian Schremmer , Dirk Steinritz , Thomas Gudermann , David J Beech , Alexander Dietrich

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension.

Circulation research

Avec: Bastien Masson , Hélène Le Ribeuz , Jessica Sabourin , Loann Laubry , Emily Woodhouse , Richard Foster , Yann Ruchon , Mary Dutheil , Angèle Boët , Maria-Rosa Ghigna , Vincent Thomas De Montpreville , Olaf Mercier , David J Beech , Jean-Pierre Benitah , Marc A Bailey , Marc Humbert , David Montani , Véronique Capuano , Fabrice Antigny

Nitric oxide synthase phosphorylation in fetoplacental endothelium is enhanced by agonism of Piezo1 mechanosensor in small for gestational age babies.

Reproduction & fertility

Avec: L C Morley , M Debant , H J Gaunt , N A B Simpson , D J Beech

PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.

Communications biology

Avec: Eulashini Chuntharpursat-Bon , Oleksandr V Povstyan , Melanie J Ludlow , David J Carrier , Marjolaine Debant , Jian Shi , Hannah J Gaunt , Claudia C Bauer , Alistair Curd , T Simon Futers , Paul D Baxter , Michelle Peckham , Stephen P Muench , Antony Adamson , Neil Humphreys , Sarka Tumova , Robin S Bon , Richard Cubbon , Laeticia Lichtenstein , David J Beech

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.

Bone research

Avec: Laura J Brylka , Assil-Ramin Alimy , Miriam E A Tschaffon-Müller , Shan Jiang , Tobias Malte Ballhause , Anke Baranowsky , Simon von Kroge , Julian Delsmann , Eva Pawlus , Kian Eghbalian , Klaus Püschel , Astrid Schoppa , Melanie Haffner-Luntzer , David J Beech , Frank Timo Beil , Michael Amling , Johannes Keller , Anita Ignatius , Timur A Yorgan , Tim Rolvien , Thorsten Schinke

Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca

Circulation

Avec: Fiona Bartoli , Marc A Bailey , Baptiste Rode , Philippe Mateo , Fabrice Antigny , Kaveen Bedouet , Pascale Gerbaud , Rajendra Gosain , Jeffrey Plante , Katherine Norman , Susana Gomez , Florence Lefebvre , Catherine Rucker-Martin , Justin F X Ainscough , Mark T Kearney , Alexander-Francisco Bruns , Jian Shi , Hollie L Appleby , Richard S Young , Heba M Shawer , Marjolaine Debant , Ana-Maria Gomez , David J Beech , Richard Foster , Jean-Pierre Benitah , Jessica Sabourin

Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy.

Journal of the American Heart Association

Avec: Talia Caspi , Sam Straw , Chew Cheng , Jack O Garnham , Jason L Scragg , Jessica Smith , Aaron O Koshy , Eylem Levelt , Piruthivi Sukumar , John Gierula , David J Beech , Mark T Kearney , Richard M Cubbon , Stephen B Wheatcroft , Klaus K Witte , Lee D Roberts , T Scott Bowen

Emerging concepts of shear stress in placental development and function.

Molecular human reproduction

Avec: L C Morley , D J Beech , J J Walker , N A B Simpson

Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity.

EMBO reports

Avec: Natalie J Haywood , Cheukyau Luk , Katherine I Bridge , Michael Drozd , Natallia Makava , Anna Skromna , Amanda Maccannell , Claire H Ozber , Nele Warmke , Chloe G Wilkinson , Nicole T Watt , Joanna Koch-Paszkowski , Irvin Teh , Jordan H Boyle , Sean Smart , Jurgen E Schneider , Nadira Y Yuldasheva , Lee D Roberts , David J Beech , Piruthivi Sukumar , Stephen B Wheatcroft , Richard M Cubbon , Mark T Kearney

Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition.

ACS medicinal chemistry letters

Avec: Zhenhua Wu , Jean-Simon Suppo , Sarka Tumova , Jonathan Strope , Fernando Bravo , Melody Moy , Ethan S Weinstein , Cody J Peer , William D Figg , William J Chain , Antonio M Echavarren , David J Beech , John A Beutler

Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice.

Cells

Avec: Fiona Bartoli , Elizabeth L Evans , Nicola M Blythe , Leander Stewart , Eulashini Chuntharpursat-Bon , Marjolaine Debant , Katie E Musialowski , Laeticia Lichtenstein , Gregory Parsonage , T Simon Futers , Neil A Turner , David J Beech

Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity.

The Journal of clinical investigation

Avec: Fiona Bartoli , Marjolaine Debant , Eulashini Chuntharpursat-Bon , Elizabeth L Evans , Katie E Musialowski , Gregory Parsonage , Lara C Morley , T Simon Futers , Piruthivi Sukumar , T Scott Bowen , Mark T Kearney , Laeticia Lichtenstein , Lee D Roberts , David J Beech

Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.

Endocrinology

Avec: Andrew M N Walker , Nele Warmke , Ben Mercer , Nicole T Watt , Romana Mughal , Jessica Smith , Stacey Galloway , Natalie J Haywood , Taha Soomro , Kathryn J Griffin , Stephen B Wheatcroft , Nadira Y Yuldasheva , David J Beech , Peter Carmeliet , Mark T Kearney , Richard M Cubbon

A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation.

The Journal of general physiology

Avec: Nicoletta Murciano , Maria Giustina Rotordam , Nadine Becker , Melanie J Ludlow , Gregory Parsonage , Alexis Darras , Lars Kaestner , David J Beech , Michael George , Niels Fertig , Markus Rapedius , Andrea Brüggemann

Réseau de co-auteurs

Mark T Kearney 6 collaborations

Marjolaine Debant 5 collaborations

Piruthivi Sukumar 5 collaborations

T Simon Futers 4 collaborations

Laeticia Lichtenstein 4 collaborations

Fiona Bartoli 4 collaborations

Gregory Parsonage 4 collaborations

Richard M Cubbon 4 collaborations

Stephen B Wheatcroft 4 collaborations

Nadira Y Yuldasheva 3 collaborations

Natalie J Haywood 3 collaborations

Eulashini Chuntharpursat-Bon 3 collaborations

Lee D Roberts 3 collaborations

Naima Endesh 2 collaborations

Robin S Bon 2 collaborations

Anna Skromna 2 collaborations

Natallia Makava 2 collaborations

Andrew M N Walker 2 collaborations

Jessica Sabourin 2 collaborations

Richard Foster 2 collaborations

Jean-Pierre Benitah 2 collaborations

Marc A Bailey 2 collaborations

Fabrice Antigny 2 collaborations

L C Morley 2 collaborations

N A B Simpson 2 collaborations

D J Beech 2 collaborations

Melanie J Ludlow 2 collaborations

Jian Shi 2 collaborations

Sarka Tumova 2 collaborations

Jessica Smith 2 collaborations

T Scott Bowen 2 collaborations

Nele Warmke 2 collaborations

Nicole T Watt 2 collaborations

Elizabeth L Evans 2 collaborations

Katie E Musialowski 2 collaborations

Vincenza Caolo 1 collaboration

Elizabeth Av Jones 1 collaboration

Antreas C Kalli 1 collaboration

David J Wright 1 collaboration

Hema Viswambharan 1 collaboration

Helen Imrie 1 collaboration

Katherine Bridge 1 collaboration

Karen E Hemmings 1 collaboration

Emily R Clark 1 collaboration

V Kate Gatenby 1 collaboration

Paul Cordell 1 collaboration

Katie J Simmons 1 collaboration

Yilizila Abudushalamu 1 collaboration

Jane Brown 1 collaboration

Simon T Futers 1 collaboration

Karen E Porter 1 collaboration

Khalid Naseem 1 collaboration

Ajay M Shah 1 collaboration

Christian Schremmer 1 collaboration

Dirk Steinritz 1 collaboration

Thomas Gudermann 1 collaboration

Alexander Dietrich 1 collaboration

Bastien Masson 1 collaboration

Hélène Le Ribeuz 1 collaboration

Loann Laubry 1 collaboration

Emily Woodhouse 1 collaboration

Yann Ruchon 1 collaboration

Mary Dutheil 1 collaboration

Angèle Boët 1 collaboration

Maria-Rosa Ghigna 1 collaboration

Vincent Thomas De Montpreville 1 collaboration

Olaf Mercier 1 collaboration

Marc Humbert 1 collaboration

David Montani 1 collaboration

Véronique Capuano 1 collaboration

M Debant 1 collaboration

H J Gaunt 1 collaboration

Oleksandr V Povstyan 1 collaboration

David J Carrier 1 collaboration

Hannah J Gaunt 1 collaboration

Claudia C Bauer 1 collaboration

Alistair Curd 1 collaboration

Paul D Baxter 1 collaboration

Michelle Peckham 1 collaboration

Stephen P Muench 1 collaboration

Antony Adamson 1 collaboration

Neil Humphreys 1 collaboration

Richard Cubbon 1 collaboration

Laura J Brylka 1 collaboration

Assil-Ramin Alimy 1 collaboration

Miriam E A Tschaffon-Müller 1 collaboration

Shan Jiang 1 collaboration

Tobias Malte Ballhause 1 collaboration

Anke Baranowsky 1 collaboration

Simon von Kroge 1 collaboration

Julian Delsmann 1 collaboration

Eva Pawlus 1 collaboration

Kian Eghbalian 1 collaboration

Klaus Püschel 1 collaboration

Astrid Schoppa 1 collaboration

Melanie Haffner-Luntzer 1 collaboration

Frank Timo Beil 1 collaboration

Michael Amling 1 collaboration

Johannes Keller 1 collaboration

Anita Ignatius 1 collaboration

Timur A Yorgan 1 collaboration

Tim Rolvien 1 collaboration

Thorsten Schinke 1 collaboration

Baptiste Rode 1 collaboration

Philippe Mateo 1 collaboration

Kaveen Bedouet 1 collaboration

Pascale Gerbaud 1 collaboration

Rajendra Gosain 1 collaboration

Jeffrey Plante 1 collaboration

Katherine Norman 1 collaboration

Susana Gomez 1 collaboration

Florence Lefebvre 1 collaboration

Catherine Rucker-Martin 1 collaboration

Justin F X Ainscough 1 collaboration

Alexander-Francisco Bruns 1 collaboration

Hollie L Appleby 1 collaboration

Richard S Young 1 collaboration

Heba M Shawer 1 collaboration

Ana-Maria Gomez 1 collaboration

Talia Caspi 1 collaboration

Sam Straw 1 collaboration

Chew Cheng 1 collaboration

Jack O Garnham 1 collaboration

Jason L Scragg 1 collaboration

Aaron O Koshy 1 collaboration

Eylem Levelt 1 collaboration

John Gierula 1 collaboration

Klaus K Witte 1 collaboration

J J Walker 1 collaboration

Cheukyau Luk 1 collaboration

Katherine I Bridge 1 collaboration

Michael Drozd 1 collaboration

Amanda Maccannell 1 collaboration

Claire H Ozber 1 collaboration

Chloe G Wilkinson 1 collaboration

Joanna Koch-Paszkowski 1 collaboration

Irvin Teh 1 collaboration

Jordan H Boyle 1 collaboration

Sean Smart 1 collaboration

Jurgen E Schneider 1 collaboration

Zhenhua Wu 1 collaboration

Jean-Simon Suppo 1 collaboration

Jonathan Strope 1 collaboration

Fernando Bravo 1 collaboration

Melody Moy 1 collaboration

Ethan S Weinstein 1 collaboration

Cody J Peer 1 collaboration

William D Figg 1 collaboration

William J Chain 1 collaboration

Antonio M Echavarren 1 collaboration

John A Beutler 1 collaboration

Nicola M Blythe 1 collaboration

Leander Stewart 1 collaboration

Neil A Turner 1 collaboration

Lara C Morley 1 collaboration

Ben Mercer 1 collaboration

Romana Mughal 1 collaboration

Stacey Galloway 1 collaboration

Taha Soomro 1 collaboration

Kathryn J Griffin 1 collaboration

Peter Carmeliet 1 collaboration

Nicoletta Murciano 1 collaboration

Maria Giustina Rotordam 1 collaboration

Nadine Becker 1 collaboration

Alexis Darras 1 collaboration

Lars Kaestner 1 collaboration

Michael George 1 collaboration

Niels Fertig 1 collaboration

Markus Rapedius 1 collaboration

Andrea Brüggemann 1 collaboration