Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells.
ADAM10 Protein
/ metabolism
Amyloid Precursor Protein Secretases
/ metabolism
Animals
Cells, Cultured
Endothelial Cells
/ metabolism
Enzyme Activation
Gene Expression Regulation
Humans
Ion Channels
/ antagonists & inhibitors
Male
Membrane Proteins
/ metabolism
Mice
Mice, Inbred C57BL
Protein Domains
Receptor, Notch1
/ metabolism
Stress, Mechanical
Transcription Factor HES-1
/ genetics
cell biology
endothelial cell
human
ion channel
mouse
notch signalling
proteinase
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 06 2020
02 06 2020
Historique:
received:
30
07
2019
accepted:
01
06
2020
pubmed:
3
6
2020
medline:
4
3
2021
entrez:
3
6
2020
Statut:
epublish
Résumé
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured microvascular endothelial cells, Piezo1 channel activation by either shear stress or a chemical agonist Yoda1 activated a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), a Ca
Identifiants
pubmed: 32484440
doi: 10.7554/eLife.50684
pii: 50684
pmc: PMC7295575
doi:
pii:
Substances chimiques
Hes1 protein, mouse
0
Ion Channels
0
Membrane Proteins
0
Notch1 protein, mouse
0
Piezo1 protein, mouse
0
Receptor, Notch1
0
Transcription Factor HES-1
0
Amyloid Precursor Protein Secretases
EC 3.4.-
ADAM10 Protein
EC 3.4.24.81
Adam10 protein, mouse
EC 3.4.24.81
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : RG/17/11/33042
Pays : United Kingdom
Organisme : European Commission
ID : H2020-MSCA-IF-2016 SAVE 748369
Pays : International
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G091018N
Pays : International
Organisme : Wellcome
ID : 110044/Z/15/Z
Pays : International
Informations de copyright
© 2020, Caolo et al.
Déclaration de conflit d'intérêts
VC, MD, NE, TF, LL, FB, GP, EJ, DB No competing interests declared
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