Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.
depression
late-life depression
medical comorbidity
polypharmacy
somatic conditions
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
02
2020
revised:
18
03
2020
accepted:
22
03
2020
pubmed:
14
5
2020
medline:
3
3
2021
entrez:
14
5
2020
Statut:
ppublish
Résumé
To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population. Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Multicentric study conducted in Australia and the United States. A total of 19,110 older adults (mean age = 75 years [standard deviation = ±4.5]). Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders. Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07-1.32), diabetes (OR = 1.22; 95% CI = 1.05-1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28-1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03-1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27-1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10-1.42), history of cancer (OR = 1.19; 95% CI = 1.05-1.34), Parkinson's disease (OR = 2.56; 95% CI = 1.83-3.56), polypharmacy (OR = 1.60; 95% CI = 1.44-1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12-1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P > .05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13-1.22). Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals. J Am Geriatr Soc 68:1834-1841, 2020.
Identifiants
pubmed: 32402115
doi: 10.1111/jgs.16468
pmc: PMC7879564
mid: NIHMS1595520
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1834-1841Subventions
Organisme : NIA NIH HHS
ID : U19 AG062682
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG029824
Pays : United States
Organisme : NIH HHS
ID : U01AG029824
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024824
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024832
Pays : United States
Informations de copyright
© 2020 The American Geriatrics Society.
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