Prenatal stress-related alterations in synaptic transmission and 5-HT
5-HT7 receptor
Sprague-Dawley rat
dorsal raphe nuclei
early life stress
serotonin
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
20
01
2020
revised:
10
04
2020
accepted:
06
05
2020
pubmed:
14
5
2020
medline:
22
6
2021
entrez:
14
5
2020
Statut:
ppublish
Résumé
Early life adversity exerts a detrimental influence on developing brain neuronal networks and its consequences may include mental health disorders. In rats, prenatal stress may lead to anxiety and depressive-like behavior in the offspring. Several lines of evidence implicated an involvement of prenatal stress in alterations of the brain serotonergic system functions, but the effects of prenatal stress on its core, the dorsal raphe nucleus (DRN), still remain incompletely understood. The present study was aimed at finding whether prenatal stress induces modifications in the glutamatergic and GABAergic inputs to DRN projection cells and whether it affects DRN 5-HT
Substances chimiques
Phenols
0
SB 269970
0
Sulfonamides
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3295-3305Subventions
Organisme : National Science Centre, Poland
ID : 2015/17/N/NZ4/02455
Organisme : Maj Institute of Pharmacology, Polish Academy of Sciences
Informations de copyright
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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