Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.

Adult Aging / drug effects Autophagy / drug effects Humans Hypoglycemic Agents / pharmacology Inflammation / metabolism Metformin / pharmacology Middle Aged Mitochondria / drug effects
T cells autophagy inflammaging metformin mitochondria

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
07 07 2020
Historique:
received: 02 05 2019
revised: 28 01 2020
accepted: 20 04 2020
pubmed: 14 5 2020
medline: 10 11 2021
entrez: 14 5 2020
Statut: ppublish

Résumé

Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4

Identifiants

DOI: 10.1016/j.cmet.2020.04.015 PMID: 32402267 PMC: PMC7217133
pubmed: 32402267
pii: S1550-4131(20)30197-2
doi: 10.1016/j.cmet.2020.04.015
pmc: PMC7217133
pii:
doi:

Substances chimiques

Hypoglycemic Agents 0
Metformin 9100L32L2N

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

44-55.e6

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK108056
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI089673
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NIDCR NIH HHS
ID : U01 DE025383
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA177558
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI042853
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001998
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007201
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025383
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Leena P Bharath (LP)

Department of Nutrition and Public Health, Merrimack College, North Andover, MA, USA.

Madhur Agrawal (M)

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA.

Grace McCambridge (G)

Department of Nutrition and Public Health, Merrimack College, North Andover, MA, USA.

Dequina A Nicholas (DA)

Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Diego, San Diego, CA, USA.

Hatice Hasturk (H)

Forsyth Institute, Cambridge, MA, USA.

Jing Liu (J)

Department of Computer Science, University of Kentucky, Lexington, KY, USA.

Kai Jiang (K)

Department of Physiology, University of Kentucky, Lexington, KY, USA.

Rui Liu (R)

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.

Zhenheng Guo (Z)

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.

Jude Deeney (J)

Department of Medicine, Endocrinology, Diabetes & Nutrition, Boston University School of Medicine, Boston, MA, USA.

Caroline M Apovian (CM)

Department of Medicine, Endocrinology, Diabetes & Nutrition, Boston University School of Medicine, Boston, MA, USA.

Jennifer Snyder-Cappione (J)

Department of Microbiology, Boston University School of Medicine, Boston, MA, USA; Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA.

Gregory S Hawk (GS)

Department of Statistics, University of Kentucky, Lexington, KY, USA.

Rebecca M Fleeman (RM)

Departments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.

Riley M F Pihl (RMF)

Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA.

Katherine Thompson (K)

Department of Statistics, University of Kentucky, Lexington, KY, USA.

Anna C Belkina (AC)

Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.

Licong Cui (L)

Department of Computer Science, University of Kentucky, Lexington, KY, USA; School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.

Elizabeth A Proctor (EA)

Departments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Departments of Biomedical Engineering, and Engineering Science & Mechanics and Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA.

Philip A Kern (PA)

Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA; Department of Medicine, University of Kentucky, Lexington, KY, USA.

Barbara S Nikolajczyk (BS)

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA. Electronic address: barb.nik@uky.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Metformin Enhances Autophagy and Normalizes...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Metformin Enhances Autophagy and Normalizes...