Narcolepsy with resolution of cataplexy and persisting orexin deficiency.
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
pubmed:
15
5
2020
medline:
24
6
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
Narcolepsy type 1 is a debilitating chronic neurological disorder, whose main symptoms of excessive daytime sleepiness and cataplexy may partially improve with time, but typically do not fully resolve. The irreversible loss of orexin neurons is considered to be the pivotal mechanistic link underlying the development of cataplectic attacks in narcolepsy type 1. Here we describe a case of untreated narcolepsy type 1with low cerebrospinal orexin levels (< 50 pg/mL), where cataplexy fully resolved in the first 5-6 years after disease onset, whereas excessive daytime sleepiness persisted.
Identifiants
pubmed: 32406370
doi: 10.5664/jcsm.8572
pmc: PMC7446074
doi:
Substances chimiques
Orexins
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1383-1386Informations de copyright
© 2020 American Academy of Sleep Medicine.
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