Dietary habits and risk of hepatocellular carcinoma among hepatitis B surface antigen carriers: A prospective cohort study in China.
diet
garlic
hepatitis B virus
hepatocellular carcinoma
prospective cohort study
Journal
Journal of digestive diseases
ISSN: 1751-2980
Titre abrégé: J Dig Dis
Pays: Australia
ID NLM: 101302699
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
24
02
2020
revised:
29
04
2020
accepted:
11
05
2020
pubmed:
15
5
2020
medline:
18
9
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
In this prospective cohort study, we aimed to evaluate the association between dietary habits and the risk of developing hepatocellular carcinoma (HCC) in hepatitis B surface antigen (HBsAg)-positive carriers in Qidong, an hepatitis B virus (HBV)-epidemic area in China. A total of 3199 HBsAg carriers aged 30-70 years in a prospective cohort in Qidong, China from 2007 to 2011 were included in the study. At baseline, all participants self-reported their dietary habits in a questionnaire interview. A follow-up check-up was performed every 6 months to identify HCC cases until November 2017. Cox's regression analysis and an interaction analysis were performed to estimate the relative risks of HCC in terms of baseline diet. Among 3199 HBsAg-positive participants, 270 developed HCC (143.86/100 000 person-years [PYs]). Compared with participants who rarely consume garlic, the risk of HCC in those who consumed it ≥ once per week decreased along with the increase in frequency (HR = 1.00, 0.90 and 0.62 in those who consumed it rarely vs those who consumed it 1-6 times per week and ≥ 7 times per week, respectively). This study found a synergistic effect between garlic and tea consumption on the risk of HCC (P = 0.039 for a multiplicative interaction). HBsAg carriers should improve their diet. Regular consumption of garlic and tea drinking may reduce the HCC incidence in HBsAg carriers.
Identifiants
pubmed: 32407579
doi: 10.1111/1751-2980.12878
doi:
Substances chimiques
Hepatitis B Surface Antigens
0
Tea
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
406-415Subventions
Organisme : China Postdoctoral Science Foundation
ID : 2019M651900
Organisme : National Natural Science Foundation of China
ID : 81703300
Organisme : National Natural Science Foundation of China
ID : 81903382
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20190652
Informations de copyright
© 2020 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
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