Regulating T-cell differentiation through the polyamine spermidine.

Animals Cell Differentiation / drug effects Colitis / immunology Immunity, Mucosal / drug effects Mice Mice, Inbred BALB C Mice, Knockout Spermidine / pharmacology T-Lymphocytes, Regulatory / immunology
Polyamines T(H)17 cells Treg cells gut immunity spermidine

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
01 2021
Historique:
received: 20 11 2019
revised: 13 03 2020
accepted: 03 04 2020
pubmed: 15 5 2020
medline: 27 7 2021
entrez: 15 5 2020
Statut: ppublish

Résumé

The cross-talk between the host and its microbiota plays a key role in the promotion of health. The production of metabolites such as polyamines by intestinal-resident bacteria is part of this symbiosis shaping host immunity. The polyamines putrescine, spermine, and spermidine are abundant within the gastrointestinal tract and might substantially contribute to gut immunity. We aimed to characterize the polyamine spermidine as a modulator of T-cell differentiation and function. Naive T cells were isolated from wild-type mice or cord blood from healthy donors and submitted to polarizing cytokines, with and without spermidine treatment, to evaluate CD4 Spermidine modulates CD4 Altogether, our results highlight the beneficial effects of spermidine, or l-arginine, on gut immunity by promoting Treg cell development.

Sections du résumé

BACKGROUND
The cross-talk between the host and its microbiota plays a key role in the promotion of health. The production of metabolites such as polyamines by intestinal-resident bacteria is part of this symbiosis shaping host immunity. The polyamines putrescine, spermine, and spermidine are abundant within the gastrointestinal tract and might substantially contribute to gut immunity.
OBJECTIVE
We aimed to characterize the polyamine spermidine as a modulator of T-cell differentiation and function.
METHODS
Naive T cells were isolated from wild-type mice or cord blood from healthy donors and submitted to polarizing cytokines, with and without spermidine treatment, to evaluate CD4
RESULTS
Spermidine modulates CD4
CONCLUSION
Altogether, our results highlight the beneficial effects of spermidine, or l-arginine, on gut immunity by promoting Treg cell development.

Identifiants

DOI: 10.1016/j.jaci.2020.04.037 PMID: 32407834
pubmed: 32407834
pii: S0091-6749(20)30637-0
doi: 10.1016/j.jaci.2020.04.037
pii:
doi:

Substances chimiques

Spermidine U87FK77H25

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-348.e11

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Guilhermina M Carriche (GM)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Luís Almeida (L)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Philipp Stüve (P)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Lis Velasquez (L)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Ayesha Dhillon-LaBrooy (A)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Urmi Roy (U)

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Marc Lindenberg (M)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.

Till Strowig (T)

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany; Hannover Medical School, Hannover, Germany.

Carlos Plaza-Sirvent (C)

Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

Ingo Schmitz (I)

Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Systems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany; Department of Molecular Immunology, Ruhr-University Bochum, Bochum, Germany.

Matthias Lochner (M)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

Anna Katharina Simon (AK)

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.

Tim Sparwasser (T)

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. Electronic address: sparwasser@uni-mainz.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Regulating T-cell differentiation through the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Regulating T-cell differentiation through the...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Regulating T-cell differentiation through the...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité muqueuse › Regulating T-cell differentiation through the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Regulating T-cell differentiation through the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Regulating T-cell differentiation through the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Regulating T-cell differentiation through the...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Spermidine › Regulating T-cell differentiation through the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Regulating T-cell differentiation through the...