Infiltrating immune cells are associated with radiosensitivity and favorable survival in head and neck cancer treated with definitive radiotherapy.
Journal
Oral surgery, oral medicine, oral pathology and oral radiology
ISSN: 2212-4411
Titre abrégé: Oral Surg Oral Med Oral Pathol Oral Radiol
Pays: United States
ID NLM: 101576782
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
22
10
2019
revised:
24
12
2019
accepted:
08
02
2020
pubmed:
16
5
2020
medline:
25
8
2020
entrez:
16
5
2020
Statut:
ppublish
Résumé
The aim of this study was to investigate the influence of CD4 Immunohistochemical staining for CD4, CD8, FoxP3 and CD1a was performed in 82 primarily chemoirradiated head and neck squamous cell carcinomas. Associations with clinicopathologic data, programmed cell death protein-1 (PD-1), programmed cell death ligand-1 (PD-L1), p16, radiation response, and survival were examined. High CD4 expression was associated with complete response after radiation (P = .006) and high CD1a expression (P = .024). High CD8 T-cell activation (high CD4, CD8 and FoxP3 expression) is associated with radio response and favorable survival in advanced head and neck cancer treated with definitive chemoradiation.
Identifiants
pubmed: 32409191
pii: S2212-4403(20)30060-2
doi: 10.1016/j.oooo.2020.02.010
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
612-620Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.