Interaction between drugs and the gut microbiome.
Animals
Antineoplastic Agents, Immunological
/ therapeutic use
Drug-Related Side Effects and Adverse Reactions
Gastrointestinal Microbiome
/ drug effects
Humans
Hypoglycemic Agents
/ pharmacology
Immune Checkpoint Inhibitors
/ therapeutic use
Immune System Phenomena
/ physiology
Metformin
/ pharmacology
Pharmaceutical Preparations
/ metabolism
Pharmacology
Proton Pump Inhibitors
/ pharmacology
drug metabolism
immunotherapy
intestinal microbiology
proton pump inhibition
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
30
03
2020
revised:
21
04
2020
accepted:
28
04
2020
pubmed:
16
5
2020
medline:
1
4
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
The human gut microbiome is a complex ecosystem that can mediate the interaction of the human host with their environment. The interaction between gut microbes and commonly used non-antibiotic drugs is complex and bidirectional: gut microbiome composition can be influenced by drugs, but, vice versa, the gut microbiome can also influence an individual's response to a drug by enzymatically transforming the drug's structure and altering its bioavailability, bioactivity or toxicity (pharmacomicrobiomics). The gut microbiome can also indirectly impact an individual's response to immunotherapy in cancer treatment. In this review we discuss the bidirectional interactions between microbes and drugs, describe the changes in gut microbiota induced by commonly used non-antibiotic drugs, and their potential clinical consequences and summarise how the microbiome impacts drug effectiveness and its role in immunotherapy. Understanding how the microbiome metabolises drugs and reduces treatment efficacy will unlock the possibility of modulating the gut microbiome to improve treatment.
Identifiants
pubmed: 32409589
pii: gutjnl-2019-320204
doi: 10.1136/gutjnl-2019-320204
pmc: PMC7398478
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
Hypoglycemic Agents
0
Immune Checkpoint Inhibitors
0
Pharmaceutical Preparations
0
Proton Pump Inhibitors
0
Metformin
9100L32L2N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1510-1519Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: RKW has received unrestricted Research Grants from Takeda, Johnson & Johnson, Ferring and Tramedico and speakers fees from Abbvie, MSD and Boston Scientific and has acted as a consultant for Takeda Pharmaceuticals.
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