Diabetic ketoacidosis.
Journal
Nature reviews. Disease primers
ISSN: 2056-676X
Titre abrégé: Nat Rev Dis Primers
Pays: England
ID NLM: 101672103
Informations de publication
Date de publication:
14 05 2020
14 05 2020
Historique:
accepted:
23
03
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Diabetic ketoacidosis (DKA) is the most common acute hyperglycaemic emergency in people with diabetes mellitus. A diagnosis of DKA is confirmed when all of the three criteria are present - 'D', either elevated blood glucose levels or a family history of diabetes mellitus; 'K', the presence of high urinary or blood ketoacids; and 'A', a high anion gap metabolic acidosis. Early diagnosis and management are paramount to improve patient outcomes. The mainstays of treatment include restoration of circulating volume, insulin therapy, electrolyte replacement and treatment of any underlying precipitating event. Without optimal treatment, DKA remains a condition with appreciable, although largely preventable, morbidity and mortality. In this Primer, we discuss the epidemiology, pathogenesis, risk factors and diagnosis of DKA and provide practical recommendations for the management of DKA in adults and children.
Identifiants
pubmed: 32409703
doi: 10.1038/s41572-020-0165-1
pii: 10.1038/s41572-020-0165-1
doi:
Substances chimiques
Hypoglycemic Agents
0
Insulin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
40Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK111024
Pays : United States
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pubmed: 31478094
pmcid: 6718373
doi: 10.1007/s11892-019-1220-8