Estimation of total collagen volume: a T1 mapping versus histological comparison study in healthy Landrace pigs.
Cardiovascular magnetic resonance
Histology
T1 mapping
Total collagen volume
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
30
03
2020
accepted:
10
05
2020
pubmed:
16
5
2020
medline:
6
10
2020
entrez:
16
5
2020
Statut:
ppublish
Résumé
Right ventricular biopsy represents the gold standard for the assessment of myocardial fibrosis and collagen content. This invasive technique, however, is accompanied by perioperative complications and poor reproducibility. Extracellular volume (ECV) measured through cardiovascular magnetic resonance (CMR) has emerged as a valid surrogate method to assess fibrosis non-invasively. Nonetheless, ECV provides an overestimation of collagen concentration since it also considers interstitial space. Our study aims to investigate the feasibility of estimating total collagen volume (TCV) through CMR by comparing it with the TCV measured at histology. Seven healthy Landrace pigs were acutely instrumented closed-chest and transported to the MRI facility for measurements. For each protocol, CMR imaging at 3T was acquired. MEDIS software was used to analyze T1 mapping and ECV for both the left ventricular myocardium (LV
Identifiants
pubmed: 32409978
doi: 10.1007/s10554-020-01881-x
pii: 10.1007/s10554-020-01881-x
pmc: PMC7438377
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1761-1769Subventions
Organisme : Deutsches Zentrum für Herz-Kreislaufforschung
ID : 81X2100305
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