Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision.
amacrine cell
mouse
neuroscience
night vision
retinal circuitry
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
16
02
2020
accepted:
27
04
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
17
3
2021
Statut:
epublish
Résumé
Night vision in mammals depends fundamentally on rod photoreceptors and the well-studied rod bipolar (RB) cell pathway. The central neuron in this pathway, the AII amacrine cell (AC), exhibits a spatially tuned receptive field, composed of an excitatory center and an inhibitory surround, that propagates to ganglion cells, the retina's projection neurons. The circuitry underlying the surround of the AII, however, remains unresolved. Here, we combined structural, functional and optogenetic analyses of the mouse retina to discover that surround inhibition of the AII depends primarily on a single interneuron type, the NOS-1 AC: a multistratified, axon-bearing GABAergic cell, with dendrites in both ON and OFF synaptic layers, but with a pure ON (depolarizing) response to light. Our study demonstrates generally that novel neural circuits can be identified from targeted connectomic analyses and specifically that the NOS-1 AC mediates long-range inhibition during night vision and is a major element of the RB pathway.
Identifiants
pubmed: 32412412
doi: 10.7554/eLife.56077
pii: 56077
pmc: PMC7228767
doi:
pii:
Substances chimiques
Nitric Oxide Synthase Type I
EC 1.14.13.39
Nos1 protein, mouse
EC 1.14.13.39
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY026878
Pays : United States
Organisme : NEI NIH HHS
ID : EY017836
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY014454
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY017836
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY029820
Pays : United States
Organisme : NEI NIH HHS
ID : EY029323
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029323
Pays : United States
Informations de copyright
© 2020, Park et al.
Déclaration de conflit d'intérêts
SP, EL, JK, NR, PG, PR, NJ, HL, IK, KB, JD, JS No competing interests declared
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