Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure.
Animals
Autonomic Nervous System
/ physiopathology
Blood Pressure
Choline O-Acetyltransferase
/ genetics
Cholinergic Neurons
/ drug effects
Clozapine
/ analogs & derivatives
Heart
/ innervation
Heart Failure
/ etiology
Heart Rate
Male
Rats
Rats, Long-Evans
Ventricular Function
Ventricular Outflow Obstruction
/ complications
DREADDs
acetylcholine
autonomic
heart failure
parasympathetic
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
pubmed:
16
5
2020
medline:
7
10
2020
entrez:
16
5
2020
Statut:
ppublish
Résumé
Heart failure (HF) is characterized by autonomic imbalance with sympathetic hyperactivity and loss of parasympathetic tone. Intracardiac ganglia (ICG) neurons represent the final common pathway for vagal innervation of the heart and strongly regulate cardiac functions. This study tests whether ICG cholinergic neuron activation mitigates the progression of cardiac dysfunction and reduces mortality that occurs in HF. HF was induced by transaortic constriction (TAC) in male transgenic Long-Evans rats expressing Cre recombinase within choline acetyltransferase (ChAT) neurons. ChAT neurons were selectively activated by expression and activation of excitatory designer receptors exclusively activated by designer receptors (DREADDs) by clozapine-
Identifiants
pubmed: 32412778
doi: 10.1152/ajpheart.00150.2020
pmc: PMC7474442
doi:
Substances chimiques
Choline O-Acetyltransferase
EC 2.3.1.6
Clozapine
J60AR2IKIC
clozapine N-oxide
MZA8BK588J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H3-H12Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL133862
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146169
Pays : United States
Organisme : NIH HHS
ID : HL146169
Pays : United States
Organisme : NIH HHS
ID : HL133862
Pays : United States
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